{"id":14389,"date":"2022-08-10T14:58:56","date_gmt":"2022-08-10T13:58:56","guid":{"rendered":"https:\/\/nutrishield.com\/?p=14389"},"modified":"2022-11-18T17:03:41","modified_gmt":"2022-11-18T17:03:41","slug":"protect-mitochondria-for-longer-healthier-life","status":"publish","type":"post","link":"https:\/\/staging.nutrishield.com\/?p=14389","title":{"rendered":"Protect energy-promoting mitochondria for longer healthier life"},"content":{"rendered":"<div id=\"pl-14389\"  class=\"panel-layout\" ><div id=\"pg-14389-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14389-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14389-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Energy is essential for powering all the millions of processes that keep your body working well.<\/p>\n<p>From repairing DNA, maintaining the immune system, keeping the brain and heart functioning optimally, to healing wounds and overcoming illness.<\/p>\n<p>If energy declines, things \u2013 literally \u2013 begin to fall apart. Biological entropy. So ageing, metabolism and energy are very closely connected, and mitochondria are the key to energy.<\/p>\n<p>Mitochondria (illustrated above and here within a cell) are the tiny \u2018energy factories\u2019 in your cells that convert the food you eat into the energy you need.<\/p>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-14403 size-medium\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/08\/mitochondria-in-cell-SStk-300x169.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"169\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/mitochondria-in-cell-SStk-300x169.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/mitochondria-in-cell-SStk-768x432.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/mitochondria-in-cell-SStk.jpg 1000w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>They are a determinant of how long you live <i>(<\/i><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19756719\/\">Ref<\/a><i>).<\/i><\/p>\n<p>So protecting your mitochondria is a priority. Research shows that several phyto-nutrients (<em>phyto<\/em> means <em>plant<\/em>) are among natural food compounds that can help protect and even repair human mitochondria<span style=\"font-size: 13.3333px;\"> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4566449\/\">Ref<\/a>)<\/span>.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14389-1\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-14389-1\" ><div id=\"pgc-14389-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14389-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>&nbsp;<\/p>\n<hr \/>\n<p><span style=\"color: #800080;\"><em>Colin Rose is a Senior Associate Member of the Royal Society of Medicine, and Fellow of the Royal Society of Arts. He is the Founder and Director of Research and Innovation of Uni-Vite Healthcare and author of a recent <\/em><\/span><span style=\"color: #800080;\"><em>book: <strong>Delay Ageing: Healthy to 100<\/strong>, where he reveals how to slow ageing and, therefore, help prevent later-life illness.<\/em><\/span><\/p>\n<p>On why he wrote this series of articles on how to live <strong>A Longer, Healthier Life<\/strong>, Colin says:<\/p>\n<blockquote>\n<p>\"The following chart \u2013 created by the <em>American Association for the Advancement of Science \u2013 <\/em>is sobering.<\/p>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-14485 size-full\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/Age-related-Diseases-graph-AmAAS.png\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"637\" height=\"358\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/Age-related-Diseases-graph-AmAAS.png 637w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/Age-related-Diseases-graph-AmAAS-300x169.png 300w\" sizes=\"(max-width: 637px) 100vw, 637px\" \/><\/p>\n<p>\"Why the steep increase in all these health threats after the age of say 55? Previously we might have muttered \u2013 \u201c<em>Just getting older, what can you expect<\/em>?\u201d<\/p>\n<p>\"But a mountain of recent research has uncovered the processes that are driving <u>all<\/u> these age-related diseases <strong>and how to counteract them<\/strong> for a longer, healthier life.<\/p>\n<p>\"That\u2019s what I explore in this series.\"<\/p>\n<\/blockquote>\n<hr \/>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-14389-2\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14389-2-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14389-2-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Protecting your mitochondria with nutrients<\/strong><\/h2>\n<h3>Polyphenols<\/h3>\n<p>A recent study <span style=\"font-size: 13.3333px;\">(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4566449\/\">Ref<\/a>)<\/span> singled out a number of these phyto-nutrients as of particular importance. They include:<\/p>\n<p><strong>RESVERATROL<\/strong> \u2013 grapeseed extract, blueberries, bilberries and grape skins<\/p>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-8447 size-medium\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-black-bunch-C-253x300.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"253\" height=\"300\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-black-bunch-C-253x300.jpg 253w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-black-bunch-C.jpg 305w\" sizes=\"(max-width: 253px) 100vw, 253px\" \/><\/p>\n<p><strong>SOY ISOFLAVONES \u2013<\/strong>\u00a0soybeans and soya foods<\/p>\n<p><strong>GREEN TEA<\/strong><\/p>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-3567 size-medium\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2013\/04\/greenTea-296x300.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"296\" height=\"300\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/greenTea-296x300.jpg 296w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/greenTea-80x80.jpg 80w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/greenTea-36x36.jpg 36w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/greenTea.jpg 352w\" sizes=\"(max-width: 296px) 100vw, 296px\" \/><\/p>\n<p><strong>QUERCETIN<\/strong> \u2013 capers, asparagus, red onions, parsley, dark berry fruits, apples, kale)<\/p>\n<p><strong>MALATE<\/strong> \u2013 apples<\/p>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-6285\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/12\/apple-red.bmp\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"250\" height=\"300\" \/><\/p>\n<p>The generic name for these natural plant organic compounds is \u2018<em>polyphenols<\/em>\u2019.<\/p>\n<p>Polyphenols typically represent only one-thousandth of the weight of fruits and vegetables. But just like vitamins and minerals, which are also only a tiny fraction of your plant food intake, they are central to your health.<\/p>\n<h3>Other Nutrients<\/h3>\n<p>Other supplements that help protect mitochondria include:<\/p>\n<p><b>GLUCOSAMINE. <\/b>Whilst glucosamine is mainly thought of as a supplement to improve joints, surprising recent research<span style=\"font-size: 13.3333px;\"> (<a href=\"https:\/\/www.nature.com\/articles\/ncomms4563\">Ref<\/a>)<\/span> shows it helps the formation of new mitochondria, helps counteract inflammation and extends life in animal studies (<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jag\/65\/3\/65_jag.JAG-2018_002\/_html\/-char\/en\">Ref.<\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24444050\/\">Ref.<\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5664031\/\">Ref. <\/a>)<\/p>\n<p><strong>CURCUMIN <\/strong>\u2013 the highly concentrated extract derived from the spice turmeric \u2013 is known to be an especially powerful antioxidant and anti-inflammatory compound and therefore has wide health benefits<span style=\"font-size: 13.3333px;\"> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5664031\/\">Ref<\/a>)<\/span>.<\/p>\n<ul>\n<li style=\"list-style-type: none;\"><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-3579 size-medium\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric-296x300.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"296\" height=\"300\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric-296x300.jpg 296w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric-80x80.jpg 80w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric-36x36.jpg 36w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric.jpg 352w\" sizes=\"(max-width: 296px) 100vw, 296px\" \/><\/li>\n<\/ul>\n<p>A 2020 study (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31580521\/\">Ref<\/a>)\u00a0 confirms that curcumin helps protect against mitochondrial dysfunction, stating: \u201c<em>curcumin has considerable mitochondria-protective properties\u201d<\/em> and importantly acts \u201c<em>against broad-spectrum neurotoxic compounds and diseases\/injury-associating neuro-degenerative diseases\u201d. <\/em>In other words, it helps protect the brain.<\/p>\n<p>However, curcumin in a supplement needs to be combined with a patented black pepper compound (called Bioperine) and a fat source to enhance its otherwise poor bioavailability (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7144558\/\">Ref<\/a>). Turmeric itself is <u>very<\/u> poorly absorbed in the gut.<\/p>\n<p><b>OMEGA 3 <\/b>is a fatty acid found mainly in oily fish like salmon, but also in flaxseeds and walnuts and supplements.<\/p>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-8767 size-medium\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2018\/07\/walnuts-C-300x203.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"203\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/07\/walnuts-C-300x203.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/07\/walnuts-C-705x477.jpg 705w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/07\/walnuts-C-450x305.jpg 450w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/07\/walnuts-C.jpg 728w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Omega 3 is needed to build healthy mitochondrial cell walls <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24396061\/\">(Ref)<\/a>. An article in the <em>Journal of Physiology<\/em> shows that supplementation with Omega 3 improved the composition of mitochondrial membranes \u2013 cell walls \u2013 leading to reduced free radical damage and increased energy.<\/p>\n<p>A 2021 study of 2,250 people over 65 and published in <em>The American Journal of Clinical Nutrition<\/em> indicates a potential increase in life expectancy from a high intake of Omega 3 alone of up to 5 years! It also showed improved cognition in people with mild Alzheimer\u2019s.<\/p>\n<p><strong>CO Q10.<\/strong> Finally, many people do not realise that mitochondria have their own DNA. But when glucose and fats are metabolised in the presence of oxygen by the mitochondria to create energy, damaging free radicals are produced (it\u2019s also called oxidative stress.).<\/p>\n<p>This \u2018biological collateral damage\u2019 accumulates over time and is known to be a key cause of ageing.<\/p>\n<p>The body does produce CoQ10 to protect mitochondrial DNA , but levels decline with age. Supplementing with CoQ10 helps prevent this damage (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15620378\/\">Ref )<\/a>.<\/p>\n<p>Indeed, one animal study showed that supplementing with CoQ10 produced an 11.7% increase in average lifespan. <a href=\"https:\/\/www.semanticscholar.org\/paper\/Coenzyme-Q-supplementation-protects-from-DNA-breaks-Quiles-Ochoa\/a9e9d289ce72383d9f0cc8f0dfaeea2c6b66dcc2\">(Ref)<\/a> In human terms, this could theoretically translate to a 9-year increase in lifespan.<\/p>\n<p>In addition, the antioxidants in many fruits and vegetables help counter both general cellular <u>and<\/u> mitochondrial oxidative damage.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14389-3\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14389-3-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14389-3-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><!-- wp:image {\"id\":8961,\"align\":\"center\",\"linkDestination\":\"custom\"} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:html --><\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<h2><strong>Improving energy directly \u2013 NAD+ and CoQ10<\/strong><\/h2>\n<p>How can we directly improve energy production?<\/p>\n<p>You may (or probably may not!) remember from school biology that the production of energy involves the fiendishly complex <em>Krebs Cycle<\/em>. But don\u2019t worry \u2013 we\u2019ll keep it as simple as needed!<\/p>\n<p>&nbsp;<\/p>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-14395 size-large\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/08\/krebs-cycle-plus-NADATP-SStk-and-CR-1030x637.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"1030\" height=\"637\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/krebs-cycle-plus-NADATP-SStk-and-CR-1030x637.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/krebs-cycle-plus-NADATP-SStk-and-CR-300x185.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/krebs-cycle-plus-NADATP-SStk-and-CR-768x475.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/krebs-cycle-plus-NADATP-SStk-and-CR-1536x949.jpg 1536w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/krebs-cycle-plus-NADATP-SStk-and-CR-2048x1266.jpg 2048w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/><\/p>\n<h3>NAD+<\/h3>\n<p>Food is broken down into glucose which enters the cell and then the mitochondria. Within the mitochondria, the B3 vitamin nicotinamide (also called nicotinic acid) enables it to be converted to a co-enzyme molecule called NAD+, which is a vital input into the Krebs Cycle.<\/p>\n<p>Eventually the whole process produces ATP \u2013 the energy molecule that we need huge amounts of to function.<\/p>\n<p>So, nicotinamide is a precursor to NAD+ and therefore essential to the process of creating ATP. But other B vitamins are involved, too. Which is why optimum levels of all B complex vitamins are essential to energy, as is magnesium.<\/p>\n<p>But that\u2019s not the whole story. Because there is another part of the Krebs Cycle.<\/p>\n<h3>CoQ10<\/h3>\n<p>Another co-enzyme called CoQ10 is an essential part of that and, therefore, vital for energy production. (For biology nerds like me, this second part of the Krebs Cycle is called the Electron Transport Chain.)<\/p>\n<p>Both NAD+ levels and CoQ10 levels decline with age (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5088772\/\">Ref<\/a>). CoQ10 levels also decline with statin use so many doctors recommend that statin users supplement with CoQ10 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24170646\/\">Ref<\/a>).<\/p>\n<p>The evidence for supplementing with CoQ10 to increase energy on its own is mixed (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17914161\/\">Ref<\/a>) \u2013 but it is an antioxidant and has a supporting role to play in a truly comprehensive healthy ageing and cardio-support supplement (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29766349\/\">Ref<\/a>).<\/p>\n<p>The evidence for boosting NAD+, however, is strong (<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/acel.12935\">Ref<\/a>). Indeed, <em>Scientific American<\/em> calls NAD \u201c<em>the linchpin of energy metabolism.\u201d<\/em><\/p>\n<p>The question, though, is how to increase it to boost flagging energy levels?<\/p>\n<h2><strong>Can you supplement with NAD+?<\/strong><\/h2>\n<p>It is true that NAD+ is a critical step in the process that creates energy (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27825999\/\">Ref<\/a>). In addition, NAD+ indirectly supports DNA repair, <u>and<\/u> is involved in turning key genes called <em><strong>sirtuin<\/strong><\/em> genes on and off (<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/acel.12935\">Ref<\/a>).<\/p>\n<p>Sirtuins support the creation of new healthy mitochondria and the regeneration of cells \u2013 and are deeply involved in longevity. Indeed, sirtuins were the subject of a major 2017 paper in <em>Biogerontology<\/em> titled: <em>Sirtuins, a promising target in slowing down the ageing process. <\/em><\/p>\n<p>So, nicotinamide increases NAD+ which activates sirtuins. We\u2019ll meet sirtuin genes again in a later part on genetic rejuvenation.<\/p>\n<p>To return to NAD+, the body has an increasing demand for energy and NAD+ as we get older \u2013 at precisely the time when levels of NAD+ begin to fall. The result is that by middle age levels of NAD+ may be about half what they were in your early twenties.<\/p>\n<p>So, energy levels decline, which impairs key biological functions. When the body is deficient in NAD+, it is rather like a battery that is running low on power.<\/p>\n<h3><strong>NAD+ is unstable \u2013 supplement with vitamin B3, its precursor<\/strong><\/h3>\n<p>Consequently, there has been a significant recent interest in supplements that boost NAD+. Because increasing NAD+ will not only increase ATP and therefore energy, but also helps repair DNA.<\/p>\n<p>But you cannot supplement directly with NAD+ because the molecule is unstable and breaks down before cells have a chance to absorb it.\u00a0 So you should supplement with the <em>precursor<\/em> of NAD+. Which is <strong>vitamin B3<\/strong>.<\/p>\n<h3>Which form of vitamin B3 to use? There are several!<\/h3>\n<p>There are several forms of vitamin B3, each slightly different in chemical form. And they each work differently. These are as follows.<\/p>\n<p><span style=\"color: #008000;\">VITAMIN B3 as<\/span><strong><span style=\"color: #008000;\"> NIACIN<\/span><\/strong><br \/>\nBut supplementing with niacin causes skin flushing at therapeutic doses.<\/p>\n<hr \/>\n<p><span style=\"color: #008000;\">VITAMIN B3 as <strong>NICOTINAMIDE <\/strong>(also known as niacinamide). Abbreviated name <span style=\"color: #ff0000;\"><strong>NAM<\/strong><\/span>.<\/span><\/p>\n<p><em><strong>Nicotinamide<\/strong><\/em> is the most common form of vitamin B3 in traditional vitamin supplements. It has decades of research behind it and is inexpensive. Indeed, it is a regular treatment for a type of skin cancer and a 2020 review (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32903806\/\">Ref<\/a>) reports:<\/p>\n<blockquote>\n<p><em>\u201cNumerous data suggest that nicotinamide may offer therapeutic benefits in neurodegenerative disorders, including Alzheimer's Disease.\u201d <\/em><\/p>\n<\/blockquote>\n<p>In addition, nicotinamide (NAM) is known to activate an enzyme (called PARP1) in healthy cells which supports DNA repair (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3208503\/\">Ref<\/a>), and it inhibits an enzymatic process in cancerous cells (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32903806\/\">Ref<\/a>).<\/p>\n<p>Nicotinamide (NAM) even seems to improve body composition. A 2020 study (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32386566\/\">Ref<\/a>) published in\u00a0<em>Cell Metabolism<\/em> showed that supplementing with nicotinamide (NAM) produced a decrease in whole-body fat percentage and increased muscle mass. Indeed, visceral fat (the most dangerous type of fat around the organs) was decreased by a quarter. Liver fat was also significantly decreased.<\/p>\n<p>So, you\u2019ll want some B3 as <em>nicotinamide (NAM)<\/em> in a supplement. <u>But not too much<\/u> \u2013 as we will explain soon.<\/p>\n<hr \/>\n<p><span style=\"color: #008000;\">VITAMIN B3 as <strong>NICOTINAMIDE MONONUCLEOTIDE<\/strong>. Abbreviated name <span style=\"color: #ff0000;\"><strong>NMN<\/strong><\/span>.\u00a0<\/span><\/p>\n<p>There is a third B3 version called NMN (<strong><em>Nicotinamide Mononucleotide<\/em><\/strong>).<\/p>\n<p>The problem is that it has currently been banned as a supplement by the US FDA (Food and Drug Administration) \u2013 which recently issued this notice:<\/p>\n<p><strong><em>\u201cNMN is excluded from the dietary supplement definition under section 201(ff(3)(B)(ii) of the FD&amp;C Act (21 U.S.C. \u00a7 321(ff)(3)(B)(ii)) and may not be marketed as or in a dietary supplement.\u201d<\/em><\/strong><\/p>\n<p>That means it cannot be sold without prescription in the USA. Maybe because there is not yet a safety dossier supporting it \u2013 or maybe because Big Pharma is protecting its future use as a drug. You make up your own mind!<\/p>\n<p>On the other hand, the FDA action implies that the principle of boosting NAD+ levels with a <u>safe<\/u> NAD+ precursor does indeed have a beneficial effect.<\/p>\n<p>NMN has also NOT been approved as a Novel Food by EFSA (European Food Safety Authority) or the UK regulatory authorities. So NMN is being withdrawn from sale in the UK and Europe, too.<\/p>\n<hr \/>\n<p><span style=\"color: #008000;\"><strong><span style=\"color: #ff0000;\">OPTIMAL VERSION <\/span><\/strong>VITAMIN B3 as <strong>NICOTINAMIDE RIBOSIDE<\/strong>. Abbreviated name <span style=\"color: #ff0000;\"><strong>NR<\/strong><\/span>.<\/span><\/p>\n<p>Fortunately, there is a fourth form of B3 called <strong><em>Nicotinamide Riboside<\/em><\/strong>\u00a0or <strong>NR<\/strong>. NR is found naturally at small levels in fruits, milk and vegetables.<\/p>\n<p><strong><em>Nicotinamide Riboside<\/em><\/strong> (NR) is <em>niacin<\/em> (for which there is a huge amount of safety data) bound to a sugar molecule (<em>ribose<\/em>) and the form to be used in supplements has been patented. It has and is being extensively researched as a highly effective NAD+ activator.\u00a0 There are currently 67 human clinical trials testing NR for a variety of conditions \u2013 all related to healthy ageing. (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/results?term=nicotinamide+riboside&amp;draw=2\">Ref.)<\/a><\/p>\n<p>NR<strong> IS <\/strong>approved as a food by the US FDA, by EFSA, the Australian TGA and in the UK as a \u2018novel food\u2019 because it has extensive safety and effectiveness research behind it. Crucially, Nicotinamide Riboside (NR) has been awarded a GRAS (<strong>G<\/strong>enerally <strong>R<\/strong>ecognised <strong>A<\/strong>s<strong> S<\/strong>afe) certification by the FDA.<\/p>\n<p>NR is needed to make NAD+, the fuel that creates energy and repairs damaged DNA. NAD+ also helps stem cells to live longer and replicate more \u2013 important as. stem cell levels decline over time.<\/p>\n<p>Recent review articles have strongly supported the use of NR as a precursor to NAD+, and confirmed its superiority to other B3 versions. This includes a 2020 article in the Journal <em>Nutrients (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7352172\/\">Ref.<\/a>):<\/em><\/p>\n<blockquote>\n<p><em>\"Accumulating evidence on NR's health benefits has validated its efficiency across numerous animal and human studies for the treatment of a number of cardiovascular, neurodegenerative and metabolic disorders<\/em>.<\/p>\n<p><em>\"At the current time, NR is emerging as a leading candidate due to its bioavailability, safety, and strong ability to raise NAD+ content compared to other precursors.\"<\/em><\/p>\n<\/blockquote>\n<p>You can see from the following illustration that Nicotinamide Riboside (NR) is converted into <em><u>natural<\/u><\/em> NMN before it enters into the cell and creates NAD+.<\/p>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-14576 size-large\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/08\/NAD-precursors-1030x294.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"1030\" height=\"294\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/NAD-precursors-1030x294.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/NAD-precursors-300x86.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/NAD-precursors-768x219.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/NAD-precursors-1536x438.jpg 1536w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/08\/NAD-precursors.jpg 1970w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/><\/p>\n<p>Once NR is in the cell, it improves the functioning of your mitochondria, reduces inflammation, improves vascular health and improves metabolism \u2013 which is why intake of NR has been linked to easier weight control. (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6342515\/\">Ref.)<\/a><\/p>\n<p>Numerous studies show that the NR pathway has a beneficial effect on healthy ageing. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5884172\/\">Ref.<\/a> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413118301220\">Ref.<\/a><\/p>\n<p>But you\u2019ll see that Nicotinamide (NAM) can also be indirectly converted into NAD+. So why not just use NAM \u2013 because it is cheaper?<\/p>\n<h4><strong>Why not use the cheaper NAM instead of NMN? Because NAM can reduce the expression of vital sirtuins<\/strong><\/h4>\n<p>NAD+ activates sirtuins. Sirtuins are a very important group of enzyme proteins <u>directly<\/u> involved in regulating ageing, repairing DNA, helping supress tumour formation and regulating life span in many organisms from simpler life forms to humans.<\/p>\n<p>Too much nicotinamide (NAM) can actually reduce the expression of sirtuins. This is because NAD+ is converted into NAM in order to \u201cactivate\u201d the sirtuins. But research shows that if there is too much NAM already present, this can hinder this conversion of NAD+ into NAM, and thus proper sirtuin functioning (<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0107729\">Ref.)<\/a><\/p>\n<p>In addition, high dose nicotinamide NAM can impair the expression of several important genes. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7277745\/\">(Ref.)<\/a><\/p>\n<p>So, intake of nicotinamide NAM as a supplement should be kept below 40 - 50mg a day. [It is 24 mg in NutriShield.]<\/p>\n<p>Because of its different chemical composition, NR, however, is safe at doses up to and including 250mg a day. It actually SUPPORTS sirtuin activity<\/p>\n<hr \/>\n<p>Although activating NAD+ is important, there is no one magic bullet to delay ageing. Protecting your mitochondria, increasing NAD+ and energy are just individual pieces of a big jigsaw.<\/p>\n<h2><strong>Activity levels, mitochondria and maintenance of muscle and energy<\/strong><\/h2>\n<p>We all know that exercise is vital for health. It\u2019s equally vital to maintain mitochondrial health, NAD+ levels and slow ageing.<\/p>\n<p>An article in <em>Cell Metabolism<\/em> in 2016 summarised all the evidence and concluded:<\/p>\n<blockquote>\n<p><em>\u201cPhysical inactivity and sedentary behaviour have a deleterious effect on human health that is comparable to smoking. <\/em><\/p>\n<p><em>\u201cThus, physical activity and prescribed exercise are potent counter-measures against \u2026 aging and together play a major role in the prevention of the most deadly chronic diseases modern humans face, including cardiovascular diseases, metabolic diseases, cancer, pulmonary diseases, immune dysfunction, musculoskeletal disorders, and neurological disorders\u201d.<\/em><\/p>\n<\/blockquote>\n<p>Intriguingly, the authors introduce the idea of \u201c<strong>exercise snacking<\/strong>\u201d.<\/p>\n<p>An example: 3 short (3 minute) bouts of fast paced walking before breakfast, mid-day and dinner. These 9 minutes coupled with the 7 minute a day strength exercises illustrated in the book <em>Delay Ageing<\/em> would be a realistic minimum.<\/p>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-medium wp-image-13867\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2021\/11\/oldagecouple-300x200.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"200\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/oldagecouple-300x200.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/oldagecouple-768x512.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/oldagecouple-272x182.jpg 272w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/oldagecouple.jpg 1000w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A 2022 study in <em>Nature Ageing<\/em> and titled <em>Healthy aging and muscle function are positively associated with NAD+ abundance in humans<\/em> concluded:<\/p>\n<blockquote>\n<p><em>\u201cNAD+ abundance positively correlated with average number of steps per day and mitochondrial and muscle functioning. Our work suggests that a clear association exists between NAD+ and health status in human aging\u201d.<\/em><\/p>\n<\/blockquote>\n<p>Interestingly, the same article noted that boosting NAD+ helped alleviate dry eye \u2013 a macular degeneration. Just another example of how all is connected.<\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14389-3-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"4\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Summary \u2013 How to protect mitochondria<\/strong><\/h2>\n<p>Nicotinamide (NAM) and Nicotinamide Riboside (NR) are versions of vitamin B3 that are critical to creating NAD+ and therefore ATP and energy.<\/p>\n<p>The other advantage of NAM and NR is that they reduce inflammation and increase joint flexibility and mobility in arthritis sufferers. The other B complex vitamins also directly support NAD+ production.<\/p>\n<p>CoQ10 supports repair of mitochondria.<\/p>\n<p>Grapeseed extract, curcumin, soy isoflavones and green tea extract are phyto-nutrients that can help protect mitochondria \u2013 as do glucosamine and Omega 3.<\/p>\n<p>All these natural ingredients (except NMN) are in the supplement NutriShield: <a href=\"https:\/\/nutrishield.com\/\">NutriShield | Daily Nutritional Health Supplement from Uni-Vite Healthcare.<\/a><\/p>\n<p>We will be introducing an NR supplement in early 2023.<\/p>\n<p><a href=\"https:\/\/nutrishield.com\/healthy-eating-and-lifestyle-plan-to-delay-ageing\/\">Check out the Delay Ageing Healthy Eating and Lifestyle Plan here.<\/a><\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14389-4\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14389-4-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14389-4-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"5\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-13708 alignleft\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2021\/07\/Colin-Rose-300x300.png\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"100\" height=\"100\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/07\/Colin-Rose-300x300.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/07\/Colin-Rose-80x80.png 80w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/07\/Colin-Rose.png 500w\" sizes=\"(max-width: 100px) 100vw, 100px\" \/><\/p>\n<h3>Thanks for reading<\/h3>\n<p>I spend my time researching the new science of healthy, successful ageing. \u00a0And how to extend <em>health<\/em> span rather than just <em>life<\/em>span.<\/p>\n<p>I hope you got value from this part of the 5-part series. Links to the other 4 parts are:<\/p>\n<p style=\"padding-left: 40px;\"><a href=\"https:\/\/nutrishield.com\/protect-mitochondria-for-longer-healthier-life\/\">Longer Healthier Life Part 1: Protect Energy-Promoting Mitochondria<\/a><a href=\"https:\/\/nutrishield.com\/protecting-mitochondria-leads-to-longer-healthier-life\/\"><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-13839\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2021\/11\/nutrishieldreducefatigue-80x80.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"38\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/nutrishieldreducefatigue-300x188.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/nutrishieldreducefatigue.jpg 536w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\"><a href=\"https:\/\/nutrishield.com\/the-right-nutrients-protect-dna-for-longer-healthier-life\/\">Longer Healthier Life Part 2: The Right Nutrients Can Protect Your DNA<\/a><a href=\"https:\/\/nutrishield.com\/the-right-nutrients-can-protect-your-dna\/\"><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-14430\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/DNA-broken-SStk-80x80.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"34\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/DNA-broken-SStk-300x169.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/DNA-broken-SStk-768x432.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/DNA-broken-SStk.jpg 1000w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\"><a href=\"https:\/\/nutrishield.com\/clear-zombie-cells-for-longer-healthier-life\/\">Longer Healthier Life Part 3: Clear Zombie Cells to Stay Health<\/a><a href=\"https:\/\/nutrishield.com\/clear-zombie-cells-to-stay-healthy\/\"><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-14437\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk-80x80.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"40\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk-300x200.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk-768x512.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk-272x182.jpg 272w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk.jpg 1000w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><\/a>y<\/p>\n<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\"><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-14461\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/dna-gene-80x80.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"33\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/dna-gene-300x164.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/dna-gene-768x419.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/dna-gene.jpg 998w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><a href=\"https:\/\/nutrishield.com\/switch-on-good-genes-for-longer-healthier-life\/\">Longer Healthier Life Part 4: Switching On Good Protective Genes<\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\"><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-13847\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield-80x80.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"33\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield-300x166.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield-1030x571.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield-768x425.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield.jpg 1379w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><a href=\"https:\/\/nutrishield.com\/defeat-inflammation-and-boost-immune-system-for-longer-healthier-life\/\">Longer Healthier Life Part 5: Defeating Inflammation and Boosting Your Immune System<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>And if you enjoyed it, please send the link of <strong>this article<\/strong> to any friend or family member who might benefit.<\/p>\n<p><em>Colin Rose<\/em><\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14389-4-0-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"6\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><!-- wp:image {\"id\":8961,\"align\":\"center\",\"linkDestination\":\"custom\"} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:html --><\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<h2>NutriShield Premium Health Supplement<\/h2>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-14200 size-large\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L-1030x564.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"1030\" height=\"564\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L-1030x564.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L-300x164.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L-768x420.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L.jpg 1200w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/>NutriShield Premium was originally designed by Dr Paul Clayton, former Chair of the Forum on Food and Health at the Royal Society of Medicine.<\/p>\n<p>It contains 6 different capsules, combining a total of 43 powerful nutrients to support healthy ageing and has been updated and improved every year since 2002 based on the newest longevity research.<\/p>\n<p><a href=\"http:\/\/nutrishield.com\">See NutriShield Premium here.<\/a><\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14389-4-0-2\" class=\"so-panel widget widget_sow-editor\" data-index=\"7\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><!-- wp:image {\"id\":8961,\"align\":\"center\",\"linkDestination\":\"custom\"} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:html --><\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<h3><em>Delay Ageing<\/em> book explains the ageing process and how you can postpone it<\/h3>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-10523 size-medium alignleft\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-300x300.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"300\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-300x300.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-1030x1030.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-80x80.jpg 80w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-768x768.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-1536x1536.jpg 1536w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D.jpg 2000w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Medical researchers agree that if you slow ageing, you also delay the onset of age-related disease. And we know that it\u2019s not just nutrition. Sleep, reducing stress and cardio and strength exercise are also essential to longevity and ageing well.<\/p>\n<p>My book <em>Delay Ageing: Healthy to 100<\/em>, published in 2020, explains the latest ageing science in an accessible way.<\/p>\n<p>It\u2019s been rated 5-star and I am sure you will get a lot of benefit from it, as so many have already.<\/p>\n<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/acceleratedlearning.com\/learning\/range\/books\/delay-ageing-book\">Click here to go to the publisher's website where you can buy the printed book or Kindle version.<\/a><\/span><\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14389-4-0-3\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"8\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><!-- wp:image {\"id\":8961,\"align\":\"center\",\"linkDestination\":\"custom\"} --><\/p>\n<p><!-- \/wp:image --><!-- wp:separator --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:image {\"id\":8512,\"align\":\"center\"} --><\/p>\n<p>&nbsp;<\/p>\n<p><!-- \/wp:paragraph --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:separator --><\/p>\n<hr class=\"wp-block-separator\" \/>\n<p><!-- \/wp:separator --><!-- wp:heading {\"level\":4} --><\/p>\n<figure><a title=\"Register for free e-newsletters\" href=\"https:\/\/nutrishield.com\/newsletters\/\"><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-4565 aligncenter\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"200\" height=\"71\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-495x177.png 495w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-450x159.png 450w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter.png 500w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/><\/a><\/figure>\n<h4>And register now for a free e-newsletter on the latest in nutrition and health research.<\/h4>\n<p><!-- \/wp:heading --><!-- wp:separator --><\/p>\n<hr \/>\n<p><img  title=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-10944 size-full\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2021\/03\/Uni-VIte-supplements.jpg\"  alt=\"Protect energy-promoting mitochondria for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"1030\" height=\"302\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/03\/Uni-VIte-supplements.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/03\/Uni-VIte-supplements-300x88.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/03\/Uni-VIte-supplements-768x225.jpg 768w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/><\/p>\n<p><a href=\"https:\/\/uni-vite.com\/supplements\">You can buy our range of combination anti-ageing, anti-inflammatory and immune-supporting health supplements online from Uni-Vite, a UK company.<\/a><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:separator --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:separator --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:separator --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14389-5\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14389-5-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14389-5-0-0\" class=\"so-panel widget widget_sow-accordion panel-first-child panel-last-child\" data-index=\"9\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-accordion so-widget-sow-accordion-default-2b55ed2807e6-14389\"\n\t\t\t\n\t\t><h3 class=\"widget-title\">REFERENCES<\/h3><div>\n\t<div class=\"sow-accordion\">\n\t\t\t<div class=\"sow-accordion-panel\"\n\t\t\t data-anchor=\"links-for-5-part-series-on-slowing-ageing\">\n\t\t\t\t<div class=\"sow-accordion-panel-header-container\" role=\"heading\" aria-level=\"2\">\n\t\t\t\t\t<div class=\"sow-accordion-panel-header\" tabindex=\"0\" role=\"button\" id=\"accordion-label-links-for-5-part-series-on-slowing-ageing\" aria-controls=\"accordion-content-links-for-5-part-series-on-slowing-ageing\" aria-expanded=\"false\">\n\t\t\t\t\t\t<div class=\"sow-accordion-title sow-accordion-title-icon-left\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\tLinks for 5-part series on Slowing Ageing\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"sow-accordion-open-close-button\">\n\t\t\t\t\t\t\t<div class=\"sow-accordion-open-button\">\n\t\t\t\t\t\t\t\t<span class=\"sow-icon-ionicons\" data-sow-icon=\"&#xf218;\"\n\t\t \n\t\taria-hidden=\"true\"><\/span>\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"sow-accordion-close-button\">\n\t\t\t\t\t\t\t\t<span class=\"sow-icon-ionicons\" data-sow-icon=\"&#xf209;\"\n\t\t \n\t\taria-hidden=\"true\"><\/span>\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\n\t\t\t<div\n\t\t\t\tclass=\"sow-accordion-panel-content\"\n\t\t\t\trole=\"region\"\n\t\t\t\taria-labelledby=\"accordion-label-links-for-5-part-series-on-slowing-ageing\"\n\t\t\t\tid=\"accordion-content-links-for-5-part-series-on-slowing-ageing\"\n\t\t\t\tstyle=\"display: none;\"\t\t\t>\n\t\t\t\t<div class=\"sow-accordion-panel-border\" tabindex=\"0\">\n\t\t\t\t\t<p><strong>THEORIES OF AGEING<\/strong><\/p>\n<p><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(13)00645-4\">The Hallmarks of Aging: Cell<\/a><\/p>\n<p><a href=\"https:\/\/www.ft.com\/content\/24849908-ac4a-4a7d-b53c-847963ac1228\">Silicon Valley\u2019s billionaires want to hack the ageing process | Financial Times (ft.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19149749\/\">Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.kurzweilai.net\/how-to-prevent-a-global-aging-crisis#!prettyPhoto\">How to Prevent a Global Aging Crisis \u00ab Kurzweil (kurzweilai.net)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34488874\/#:~:text=Cellular%20reprogramming%20and%20epigenetic%20rejuvenation%20Ageing%20is%20an,and%20reversing%20the%20ageing%20process%20might%20be%20possible.\">Cellular reprogramming and epigenetic rejuvenation - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2995895\/\">Modern Biological Theories of Aging (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25519063\/\">Modern evolutionary mechanics theories and resolving the programmed\/non-programmed aging controversy - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25902456\/\">Is the Evolutionary Programmed\/ Non-programmed Aging Argument Moot? - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0531556502001614\">A Darwinian-evolutionary concept of age-related diseases - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6842891\/\">Vascular Aging: Healthy lifestyle-based approaches for successful vascular aging - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3640494\/\">Transcriptional Regulation and its Misregulation in Disease - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0167779922000257#:~:text=Regardless%2C%20reprogramming%20can%20reset%20epigenetic%20age%20to%20zero,at%20least%20at%20some%20level%2C%20a%20rejuvenation%20procedure.\">Cellular reprogramming and the rise of rejuvenation biotech - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/www.academicgates.com\/news\/story\/food-pattern-calculator-estimates-how-to-gain-up-to-ten-life-years\/10183#:~:text=A%20study%20published%20in%20PLOS%20Medicine%20on%20the,you%20could%20gain%20by%20modifications%20in%20diet%20patterns.\">Food pattern calculator estimates how to gain up to ten life years - Academic Gates<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s43587-021-00080-0?code=5279c64f-f92f-4c77-88dd-1c45d7daf3ae\">The economic value of targeting aging | Nature Aging<\/a><\/p>\n<p><a href=\"https:\/\/www.sanger.ac.uk\/news_item\/cellular-secrets-of-ageing-unlocked-by-researchers\/\">Cellular secrets of ageing unlocked by researchers \u2013 Wellcome Sanger Institute<\/a><\/p>\n<p><a href=\"https:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.0050012\">Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study | PLOS Medicine<\/a><\/p>\n<p><a href=\"https:\/\/www.nia.nih.gov\/news\/biology-aging-study-shows-why-curbing-calories-counts\">Biology of aging study shows why curbing calories counts | National Institute on Aging (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34532416\/\">Pluripotent stem cell therapy for retinal diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/ajcn\/article\/114\/4\/1447\/6301120?login=false\">Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort | The American Journal of Clinical Nutrition | Oxford Academic (oup.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.scholars.northwestern.edu\/en\/publications\/dietary-factors-gut-microbiota-and-serum-trimethylamine-n-oxide-a\">Dietary factors, gut microbiota, and serum trimethylamine-N-oxide associated with cardiovascular disease in the Hispanic Community Health Study\/Study of Latinos \u2014 Northwestern Scholars<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30112360\/\">Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer's Disease - PubMed (nih.gov)<\/a><\/p>\n<hr \/>\n<p><strong>NUTRIENT RESEARCH <\/strong><\/p>\n<p><strong>MULTI-NUTRIENT STUDIES<\/strong><\/p>\n<p><a href=\"https:\/\/www.clinicalnutritionjournal.com\/article\/S0261-5614(21)00553-7\/fulltext\">Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial - Clinical Nutrition (clinicalnutritionjournal.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3276397\/\">Influence of Dietary Components on Regulatory T Cells (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.apjtb.org\/article.asp?issn=2221-1691;year=2018;volume=8;issue=2;spage=120;epage=129;aulast=Sabahi\">Insight into DNA protection ability of medicinal herbs and potential mechanisms in hydrogen peroxide damages model Sabahi Z, Soltani F, Moein M - Asian Pac J Trop Biomed (apjtb.org)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22362552\/\">Effects of micronutrients on DNA repair - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33995644\/\">Phytochemicals in Chemoprevention: A Cost-Effective Complementary Approach - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18568016\/\">Brain foods: the effects of nutrients on brain function - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31077707\/\">Emerging senolytic agents derived from natural products - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8429479\/\">Lifestyle Adjustments in Long-COVID Management: Potential Benefits of Plant-Based Diets (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4566449\/\">Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hmbci-2016-0034\/html\">Nutritional regulation of fibroblast growth factor 21: from macronutrients to bioactive dietary compounds (degruyter.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8445631\/\">The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/cosmostrial.org\/results\/\">COcoa Supplement and Multivitamin Outcomes Study<\/a><\/p>\n<hr \/>\n<p><strong>INDIVIDUAL NUTRIENT STUDIES<\/strong><\/p>\n<p><strong>APIGENIN<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3609577\/\">Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/apigenin\">Apigenin - an overview | ScienceDirect Topics<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6472148\/\">The Therapeutic Potential of Apigenin (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6817918\/\">A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10751547\/\">Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0104321#:~:text=Apigenin%20and%20luteolin%20were%20identified%20in%20our%20U-2,of%20FOXO1%20as%20shown%20by%20live%20cell%20imaging.\">The Flavones Apigenin and Luteolin Induce FOXO1 Translocation but Inhibit Gluconeogenic and Lipogenic Gene Expression in Human Cells (plos.org)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22098587\/\">Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells - PubMed (nih.gov)<\/a><\/p>\n<p><strong>CAROTENOIDS<\/strong><strong> (includes Lutein, Lycopene)<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14748939\/\">Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/jn\/article\/135\/8\/2071S\/4664044\">How Strong Is the Evidence that Lycopene Supplementation Can Modify Biomarkers of Oxidative Damage and DNA Repair in Human Lymphocytes? | The Journal of Nutrition | Oxford Academic (oup.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5715043\/\">Dietary guidance for lutein: consideration for intake recommendations is scientifically supported (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK225469\/\">\u03b2-Carotene and Other Carotenoids - Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids - NCBI Bookshelf (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8815648\/\">[Daily intake of carotenoids (carotenes and xanthophylls) from total diet and the carotenoid content of selected vegetables and fuit] - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14748939\/\">Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes - PubMed (nih.gov)<\/a><\/p>\n<p><strong>CO-ENZYME Q10<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22885103\/\">Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPAR\u03b1 induction in 3T3-L1 preadipocytes - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17914161\/\">Bioenergetic and antioxidant properties of coenzyme Q10: recent developments - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24170646\/\">Statins' effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29766349\/\">Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34959985\/\">Nutrients to Improve Mitochondrial Function to Reduce Brain Energy Deficit and Oxidative Stress in Migraine - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9266531\/\">Coenzyme Q10 in the diet--daily intake and relative bioavailability - PubMed (nih.gov)<\/a><\/p>\n<p><strong>CURCUMIN\/TURMERIC<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5664031\/\">Curcumin: A Review of Its Effects on Human Health (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7144558\/\">Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31580521\/\">Effects of curcumin on mitochondria in neurodegenerative diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.bbc.co.uk\/programmes\/articles\/PSTGKKt3HR08tmK69w7J1b\/does-turmeric-really-help-protect-us-from-cancer\">BBC Two - Trust Me, I'm a Doctor, Series 5, Episode 3 - Does turmeric really help protect us from cancer?<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15650394\/\">Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28799796\/\">Immune modulation by curcumin: The role of interleukin-10 - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19665995\/#:~:text=Curcumin%20activates%20AMPK%20and%20suppresses%20gluconeogenic%20gene%20expression,related%20structures%20possess%20potent%20anti-oxidant%20and%20anti-inflammatory%20properties.\">Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27967217\/\">Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6518239\/\">Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro - PMC (nih.gov)<\/a><\/p>\n<p><strong>FISETIN<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21738623\/\">Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6572624\/\">Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3689181\/\">Fisetin: A Dietary Antioxidant for Health Promotion (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/mayoclinic.pure.elsevier.com\/en\/publications\/fisetin-is-a-senotherapeutic-that-extends-health-and-lifespan\">Fisetin is a senotherapeutic that extends health and lifespan \u2014 Mayo Clinic (elsevier.com)<\/a><\/p>\n<p><strong>GLUCOSAMINE<\/strong><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/ncomms4563\">D-Glucosamine supplementation extends life span of nematodes and of ageing mice | Nature Communications<\/a><\/p>\n<p><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jag\/65\/3\/65_jag.JAG-2018_002\/_html\/-char\/en\">Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction (jst.go.jp)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24444050\/\">Assessment of protective effects of glucosamine and N-acetyl glucosamine against DNA damage induced by hydrogen peroxide in human lymphocytes - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3772083\/\">Glucosamine Activates Autophagy In Vitro and In Vivo (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3557824\/\">Use of Glucosamine and Chondroitin in Relation to Mortality (nih.gov)<\/a><\/p>\n<p><strong>LUTEOLIN<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2615542\/\">Luteolin, a flavonoid with potentials for cancer prevention and therapy (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5635727\/\">Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33522240\/\">Dietary Luteolin: A Narrative Review Focusing on Its Pharmacokinetic Properties and Effects on Glycolipid Metabolism - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27377953\/#:~:text=Further%2C%20luteolin%20treatment%20directly%20elevated%20thermogenic%20gene%20expressions,browning%20and%20thermogenesis%20through%20an%20AMPK%2FPGC1%CE%B1%20pathway-mediated%20mechanism.\">Dietary luteolin activates browning and thermogenesis in mice through an AMPK\/PGC1\u03b1 pathway-mediated mechanism - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21468539\/\">Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-\u03baB modulation in HepG2 hepatocarcinoma cells - PubMed (nih.gov)<\/a><\/p>\n<p><strong>NICOTINAMIDE\/NIACIN (Vitamin B3)<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11126400\/\">Safety of high-dose nicotinamide: a review - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33196157\/\">Nicotinamide: An Update and Review of Safety &amp; Differences from Niacin - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3208503\/\">The role of PARP in DNA repair and its therapeutic exploitation (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18429699\/\">Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7226615\/\">Nicotinamide, Nicotinamide Riboside and Nicotinic Acid\u2014Emerging Roles in Replicative and Chronological Aging in Yeast (nih.gov)<\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7226615\/\">Nicotinamide, Nicotinamide Riboside and Nicotinic Acid\u2014Emerging Roles in Replicative and Chronological Aging in Yeast (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7277745\/\">Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-019-46678-8\">Nicotinamide Augments the Anti-Inflammatory Properties of Resveratrol through PARP1 Activation | Scientific Reports (nature.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27127236\/\">NAD\u207a repletion improves mitochondrial and stem cell function and enhances life span in mice - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32386566\/\">Niacin Cures Systemic NAD + Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32903806\/\">Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease \u2013 PubMed<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-018-03421-7\">Chronic\u00a0nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults | Nature Communications<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8841834\/\">The effect of niacinamide on osteoarthritis: a pilot study - PubMed (nih.gov)<\/a><\/p>\n<p><strong>OMEGA 3<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31242648\/\">Omega-3 Fatty Acids-Enriched Fish Oil Activates AMPK\/PGC-1\u03b1 Signaling and Prevents Obesity-Related Skeletal Muscle Wasting - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3545053\/\">Omega-3 Fatty Acids, Oxidative Stress, and Leukocyte Telomere Length: A Randomized Controlled Trial (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24396061\/\">Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22332096\/\">Omega-3 fatty acids EPA and DHA: health benefits throughout life - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2451847619300387#:~:text=The%20current%20study%20has%20shown%20that%20omega-3%20fatty,decrease%20gene%20expression%20of%20UCP-2%20in%20CAD%20patients.\">Omega-3 fatty acids and vitamin E supplementation can affect gene expressions of SIRT1, FOXO1 and UCP-2 in coronary artery disease patients - ScienceDirect<\/a><\/p>\n<p><strong>POLYPHENOLS, FLAVONOIDS AND OTHER PHYTOCHEMICALS<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31412639\/\">Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24875147\/\">Polyphenols and mitochondria: an update on their increasingly emerging ROS-scavenging independent actions - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.mdpi.com\/1422-0067\/20\/20\/5090\"><u>Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer\u2019s Disease (nih.gov)<\/u> Disease (mdpi.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29703769\/\">Pattern of polyphenol intake and the long-term risk of dementia in older persons - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26325006\/\">Flavonol Intake and Cognitive Decline in Middle-Aged Adults - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5841289\/\">Natural polyphenols as sirtuin 6 modulators (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22535616\/\">Dietary intakes of berries and flavonoids in relation to cognitive decline - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/content.iospress.com\/articles\/nutrition-and-aging\/nua0051*\">Protective effects of berry polyphenols against age-related cognitive impairment - IOS Press<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27443888\/\">Potentiation of the bioavailability of blueberry phenolic compounds by co-ingested grape phenolic compounds in mice, revealed by targeted metabolomic profiling in plasma and feces - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30032176\/\">Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29854398\/\">Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6266803\/\">The Immunomodulatory and Anti-Inflammatory Role of Polyphenols (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2852857\/\">Biological Activities of Polyphenols from Grapes (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23840922\/\">Polyphenols: multipotent therapeutic agents in neurodegenerative diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30551400\/\">Phytochemicals and cognitive health: Are flavonoids doing the trick? - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20955649\/\">The impact of fruit flavonoids on memory and cognition - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31329250\/\">Recent Research on the Health Benefits of Blueberries and Their Anthocyanins - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33466731\/\">Blueberry Supplementation in Neuronal Health and Protective Technologies for Efficient Delivery of Blueberry Anthocyanins - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7480644\/\">Potential use of polyphenols in the battle against COVID-19 (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32720577\/\">Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34946521\/\">Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp) - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6627994\/\">Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern? (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128018163000467\">Polyphenols and Aging - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6115785\/\">Effects of Polyphenol-Rich Foods on Human Health - PMC (nih.gov)<\/a> .<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29703769\/\">Pattern of polyphenol intake and the long-term risk of dementia in older persons - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6133707\/\">Dietary polyphenols promote resilience against sleep deprivation\u2013induced cognitive impairment by activating protein translation (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0960894X11006512\">Flavonoids as inhibitors of human CD38 - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/europepmc.org\/article\/PMC\/PMC4840337\">Dietary proanthocyanidins boost hepatic NAD(+) metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats. - Abstract - Europe PMC<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7504512\/\">Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/journals.lww.com\/neuroreport\/Fulltext\/2020\/08020\/Tea_polyphenols_protect_learning_and_memory_in.2.aspx\">Tea polyphenols protect learning and memory in sleep-deprived mice : NeuroReport (lww.com)<\/a><\/p>\n<p><a href=\"https:\/\/moh-it.pure.elsevier.com\/en\/publications\/specific-dietary-polyphenols-are-associated-with-sleep-quality-in\">Specific dietary (Poly)phenols are associated with sleep quality in a cohort of Italian adults \u2014 Italian Ministry of Health (elsevier.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5613902\/\">Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/europepmc.org\/article\/PMC\/PMC6405770\">Green tea extract promotes DNA repair in a yeast model. - Abstract - Europe PMC<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21641214\/\">Flavonoids as inhibitors of human CD38 - PubMed (nih.gov)<\/a><\/p>\n<p><strong>PTEROSTILBENE AND RESVERATROL<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21982274\/\">Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29210129\/\">Effect of resveratrol and pterostilbene on aging and longevity - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30484255\/\">Resveratrol and 1,25-dihydroxyvitamin D co-administration protects the heart against D-galactose-induced aging in rats: evaluation of serum and cardiac levels of klotho - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2899944\/\">Dietary intake of pterostilbene, a constituent of blueberries, inhibits the \u03b2-catenin\/p65 downstream signaling pathway and colon carcinogenesis in rats (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3699815\/\">Resveratrol-Activated AMPK\/SIRT1\/Autophagy in Cellular Models of Parkinson's Disease (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25669932\/\">The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29210129\/\">Effect of resveratrol and pterostilbene on aging and longevity - PubMed (nih.gov)<\/a><\/p>\n<p><strong>QUERCETIN<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4808895\/\">Quercetin, Inflammation and Immunity (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8109056\/\">Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29864946\/#:~:text=Quercetin%20not%20only%20enhanced%20mitochondrial%20membrane%20potential%2C%20oxygen,%28MMP%29-3%29%20and%20MMP-13%20could%20be%20suppressed%20by%20quercetin.\">Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK\/SIRT1 signaling pathway in OA rats - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6572624\/\">Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33860002\/\">Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases - PubMed (nih.gov)<\/a><\/p>\n<p><strong>SEAWEED<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28635652\/\">Fucaceae: A Source of Bioactive Phlorotannins - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B978012813312500011X#:~:text=Recent%20studies%20have%20demonstrated%20a%20variety%20of%20health-benefitting,including%20anticoagulant%2C%20antitumor%2C%20antithrombosis%2C%20antivirus%2C%20antioxidation%2C%20and%20immunomodulation.\">Fucoidan and Its Health Benefits - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/d1wqtxts1xzle7.cloudfront.net\/44159778\/Phlorotannins_of_the_edible_brown_seawee20160328-28027-nli846-with-cover-page-v2.pdf?Expires=1647609336&amp;Signature=JOx8Du18boeRDOey0zKiPfw1xAvrwulwfZNueu--eUO0fA4mFCJaqcbDKAr2sgLINpeLBwNYuhGhgMy5rpWhsMWK1SvYStjSzlekGOpbRdPUJKDWOdDkONZlQiRfxlgx9BBjaSsXUWCItYO9W97MTblsCB3rhEugISqb7WbajrvUoYEzTyBLayOJVjnkRszzp9VYxjh29uyDy0FSWm5gRXlupPIjXabt4tUUmHox8zM40mk2H665RBnO-v~ZRbYzHi7te68KMiDOgXOG8I2w4sqLKEjuNL8BjZZ9u1DXAIk85-9tUQG1HPI5PbOA5uOoPk8Xfddp-7RtxA2gTS4s3A__&amp;Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA\">Phlorotannins_of_the_edible_brown_seawee20160328-28027-nli846-with-cover-page-v2.pdf (d1wqtxts1xzle7.cloudfront.net)<\/a><\/p>\n<p><a href=\"https:\/\/neuro.unboundmedicine.com\/medline\/citation\/28635652\/Fucaceae:_A_Source_of_Bioactive_Phlorotannins_\">PRIME PubMed | Fucaceae: A Source of Bioactive Phlorotannins (unboundmedicine.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25026264\/\">Ascophyllan purified from Ascophyllum nodosum induces Th1 and Tc1 immune responses by promoting dendritic cell maturation - PubMed (nih.gov)<\/a><\/p>\n<p><strong>VITAMIN D<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30256915\/\">Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4399494\/\">The Role of Vitamin D in the Aging Adult (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33415918\/\">Vitamin D: a Review of its Effects on Epigenetics and Gene Regulation - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3166406\/#:~:text=These%20effects%20result%20in%20decreased%20production%20of%20inflammatory,such%20as%20IL-1%2C%20IL-6%2C%20IL-8%2C%20IL-12%20and%20TNF%CE%B1.\">Vitamin D and the Immune System (nih.gov)<\/a><\/p>\n<p><strong>OTHER INDIVIDUAL NUTRIENTS<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26092624\/\">Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer's Disease - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.researchgate.net\/publication\/358202764_A_Potential_Probiotic_Lactobacillus_plantarum_JBC5_Improves_Longevity_and_Healthy_Aging_by_Modulating_Antioxidative_Innate_Immunity_and_Serotonin-Signaling_Pathways_in_Caenorhabditis_elegans\">(PDF) A Potential Probiotic Lactobacillus plantarum JBC5 Improves Longevity and Healthy Aging by Modulating Antioxidative, Innate Immunity and Serotonin-Signaling Pathways in Caenorhabditis elegans (researchgate.net)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC64728\/\">Chlorophyllin intervention reduces aflatoxin\u2013DNA adducts in individuals at high risk for liver cancer (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.oncologynutrition.org\/erfc\/healthy-nutrition-now\/folate-and-cancer#:~:text=The%20association%20of%20folate%20to%20cancer%20is%20sometimes,or%20too%20much%20folate%20may%20contribute%20to%20cancer.\">Folate and Cancer - Oncology Nutrition DPG<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34030963\/\">Impact of the Natural Compound Urolithin A on Health, Disease, and Aging - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6128428\/\">Spermidine delays aging in humans (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6683102\/#:~:text=Numerous%20studies%20have%20suggested%20that%20soy%20isoflavones%20provide,associated%20with%20the%20menopause%20%5B%206%2C%207%20%5D.\">Biological Effect of Soy Isoflavones in the Prevention of Civilization Diseases - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5024025\/\">Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4749867\/\">The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer's Disease - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s42255-021-00491-8\">The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice | Nature Metabolism<\/a><\/p>\n<hr \/>\n<p><strong>BODY CELLS AND PROCESSES<\/strong><\/p>\n<p><strong>ALPHA-KETOGLUTARATE<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4703346\/\">Alpha-Ketoglutarate: Physiological Functions and Applications (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32877690\/\">Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5274648\/\">Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use (nih.gov)<\/a><\/p>\n<p><strong>GENES AND GENETICS<\/strong><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/ejhg2013299\">Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis | European Journal of Human Genetics (nature.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/sites\/ppmc\/articles\/PMC3336960\/\">Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ndph.ox.ac.uk\/news\/genetic-study-provides-new-evidence-that-alcohol-accelerates-biological-aging\">Genetic study provides new evidence that alcohol accelerates biological ageing \u2014 Nuffield Department of Population Health (ox.ac.uk)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18344981\/\">Genetics of gene expression and its effect on disease - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352154621001613\">Epigenetic protection: maternal touch and DNA-methylation in early life - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21716585\/#:~:text=The%20klotho%20gene%20was%20originally%20identified%20as%20a,goddess%20Klotho%20who%20spun%20the%20thread%20of%20life.\">Klotho and the aging process - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24124751\/\">Significance of the anti-aging protein Klotho - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26827953\/\">1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4783344\/\">Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5403515\/\">FOXO3 \u2013 A Major Gene for Human Longevity (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2021.746631\/full\">Frontiers | Sirtuins as Potential Therapeutic Targets for Mitigating Neuroinflammation Associated With Alzheimer\u2019s Disease | Cellular Neuroscience (frontiersin.org)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3620486\/\">The role of sirtuins in Alzheimer's disease - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22436748\/\">AMPK: a nutrient and energy sensor that maintains energy homeostasis - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21031035\/\">Nrf2, a guardian of healthspan and gatekeeper of species longevity - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7711617\/#:~:text=Nrf2-interacting%20nutrients%20The%20most%20common%20Nrf2%20nutrients%20include,fruits%2C%20and%20Lactobacillus%20in%20fermented%20foods%20%28Table%201%29.\">Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16522169\/\">Nutraceuticals synergistically promote proliferation of human stem cells - PubMed (nih.gov)<\/a><\/p>\n<p><strong>GLYCATION AND AGEs<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5643203\/\">The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9777946\/\">Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27373680\/\">Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential contributions to disease - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28096127\/\">Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases - PubMed (nih.gov)<\/a><\/p>\n<p><strong>LITHIUM<\/strong><\/p>\n<p><a href=\"https:\/\/www.medicalnewstoday.com\/articles\/308830#:~:text=Lithium%20blocks%20GSK-3%20to%20increase%20lifespan.%20What%20is,-%20a%20key%20player%20in%20the%20aging%20process.\">Lithium brings anti-aging drugs a step closer (medicalnewstoday.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41380-018-0024-6\">Lithium treatment and mechanisms of aging | Molecular Psychiatry (nature.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21301855\/\">Low-dose lithium uptake promotes longevity in humans and metazoans - PubMed (nih.gov)<\/a><\/p>\n<p><strong>METHYLATION AND METHYL DONORS<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6471069\/\">Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/biomedres.us\/fulltexts\/BJSTR.MS.ID.002893.php\">The potential of nutritional supplements: methyl donor rich food and their application in oncology (biomedres.us)<\/a><\/p>\n<p><a href=\"https:\/\/www.linkedin.com\/pulse\/role-methylation-adaptogens-dr-alexander-jimenez-\/\">(99+) The Role of Methylation Adaptogens | LinkedIn<\/a><\/p>\n<p><a href=\"https:\/\/pdfs.semanticscholar.org\/382c\/dd8b2e68f3947ff9ef286dc9b6fb3a42552e.pdf\">Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome (semanticscholar.org)<\/a><\/p>\n<p><strong>NAD+<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5088772\/\">Why NAD+ Declines during Aging: It\u2019s Destroyed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5034109\/\">Restoring stem cells \u2014 all you need is NAD+ - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/acel.12935\">NAD+ supplementation rejuvenates aged gut adult stem cells - Igarashi -2019 - Aging Cell - Wiley Online Library<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s43587-022-00174-3#:~:text=Furthermore%2C%20we%20found%20that%20in%20the%20older%20adults%2C,with%20the%20healthy%20aging%20state%20of%20the%20individual.\">Healthy aging and muscle function are positively associated with NAD+ abundance in humans | Nature Aging<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27304496\/\">Why NAD(+) Declines during Aging: It's Destroyed - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27825999\/\">NAD and the aging process: Role in life, death and everything in between - PubMed (nih.gov)<\/a><\/p>\n<p><strong>SIRTUINS<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5514220\/#:~:text=One%20of%20the%20most%20promising%20targets%20for%20anti-ageing,to%20occur%20in%20bacteria%20and%20eukaryotes%20%28including%20mammals%29.\">Sirtuins, a promising target in slowing down the ageing process (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7426493\/\">SIRT1 Activation by Natural Phytochemicals: An Overview (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.cell.com\/trends\/cell-biology\/pdf\/S0962-8924(21)00125-2.pdf\">Sirtuin 6: linking longevity with genome and epigenome stability (cell.com)<\/a><\/p>\n<p><strong>TELOMERES<\/strong><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0140673603123847\">Association between telomere length in blood and mortality in people aged 60 years or older - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19279081\/\">Multivitamin use and telomere length in women - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26839872\/\">Leukocyte Telomere Length is Associated With Serum Vitamin B12 and Homocysteine Levels in Older Adults With the Presence of Systemic Inflammation - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25803084\/\">The role of telomeres and vitamin D in cellular aging and age-related diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.semanticscholar.org\/paper\/Age-dependent-telomere-shortening-is-slowed-down-by-Furumoto-Inoue\/c0cc30badf0edd9b5b5056db90ac9d26cbf5b5b7\">[PDF] Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. | Semantic Scholar<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4234001\/\">Association Between Higher Plasma Lutein, Zeaxanthin, and Vitamin C Concentrations and Longer Telomere Length: Results of the Austrian Stroke Prevention Study (nih.gov)<\/a><\/p>\n<p><strong>OTHER<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3410706\/#:~:text=Interleukin%2010%20%28IL-10%29%20is%20a%20cytokine%20with%20potent,to%20the%20host%20and%20maintaining%20normal%20tissue%20homeostasis.\">Role of Interleukin 10 Transcriptional Regulation in Inflammation and Autoimmune Disease (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41419-018-0765-9\">Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function | Cell Death &amp; Disease (nature.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-022-04786-y\">Clonal dynamics of haematopoiesis across the human lifespan | Nature<\/a><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Energy is essential for powering all the millions of processes that keep your body working well. From repairing DNA, maintaining the immune system, keeping the brain and heart functioning optimally, to healing wounds and overcoming illness. If energy declines, things \u2013 literally \u2013 begin to fall apart. Biological entropy. So ageing, metabolism and energy are &#8230; <a title=\"Protect energy-promoting mitochondria for longer healthier life\" class=\"read-more\" href=\"https:\/\/staging.nutrishield.com\/?p=14389\" aria-label=\"More on Protect energy-promoting mitochondria for longer healthier life\">Read more<\/a><\/p>\n","protected":false},"author":5,"featured_media":13839,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_wp_rev_ctl_limit":""},"categories":[65,35],"tags":[113,140,199,216,107],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Protect energy-promoting mitochondria | NutriShield Comprehensive Health Supplements<\/title>\r\n<meta name=\"description\" content=\"Energy is essential for healthy life. 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