{"id":14476,"date":"2022-09-14T16:28:44","date_gmt":"2022-09-14T15:28:44","guid":{"rendered":"https:\/\/nutrishield.com\/?p=14476"},"modified":"2022-09-26T14:44:05","modified_gmt":"2022-09-26T13:44:05","slug":"defeat-inflammation-and-boost-immune-system-for-longer-healthier-life","status":"publish","type":"post","link":"https:\/\/staging.nutrishield.com\/?p=14476","title":{"rendered":"Defeat inflammation and boost the immune system for longer healthier life"},"content":{"rendered":"<div id=\"pl-14476\"  class=\"panel-layout\" ><div id=\"pg-14476-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14476-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14476-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>There is near universal agreement amongst health researchers that low level but continuous (chronic) inflammation in cells and tissues is a key factor in ageing itself and almost all age-related illnesses (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19149749\/\">Ref.<\/a>)<\/p>\n<p>So much so that longevity researchers use the term <strong>'inflamm-ageing'<\/strong>.<\/p>\n<p>That inflammation can be caused by excess blood sugar, malfunctioning of the immune system, environmental toxins, poor quality fats in the diet and free radical damage.<\/p>\n<p>An inflamed cell inhibits nutrients getting into the cell, toxins being removed from the cell and energy being produced.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14476-1\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-14476-1\" ><div id=\"pgc-14476-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14476-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>&nbsp;<\/p>\n<p><span style=\"color: #800080;\"><em>Colin Rose is a Senior Associate Member of the Royal Society of Medicine, and Fellow of the Royal Society of Arts. He is the Founder and Director of Research and Innovation of Uni-Vite Healthcare and author of a recent <\/em><\/span><span style=\"color: #800080;\"><em>book: <strong>Delay Ageing: Healthy to 100<\/strong>, where he reveals how to slow ageing and, therefore, help prevent later-life illness.<\/em><\/span><\/p>\n<p>On why he wrote this series of articles on how to live <strong>A Longer, Healthier Life<\/strong>, Colin says:<\/p>\n<blockquote><p>\"The following chart \u2013 created by the <em>American Association for the Advancement of Science \u2013 <\/em>is sobering.<\/p>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-14485 size-full\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/Age-related-Diseases-graph-AmAAS.png\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"637\" height=\"358\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/Age-related-Diseases-graph-AmAAS.png 637w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/Age-related-Diseases-graph-AmAAS-300x169.png 300w\" sizes=\"(max-width: 637px) 100vw, 637px\" \/><\/p>\n<p>\"Why the steep increase in all these health threats after the age of say 55? Previously we might have muttered \u2013 \u201c<em>Just getting older, what can you expect<\/em>?\u201d<\/p>\n<p>\"But a mountain of recent research has uncovered the processes that are driving <u>all<\/u> these age-related diseases <strong>and how to counteract them<\/strong> for a longer, healthier life.<\/p>\n<p>\"That\u2019s what I explore in this series.\"<\/p><\/blockquote>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-14476-2\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14476-2-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14476-2-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Acute (temporary) vs. Chronic (long-term) inflammation<\/strong><\/h2>\n<p>If you are bitten by an insect, suffer a bacterial infection or receive a cut, your body activates your immune system, and sends out inflammatory cells (called cytokines). Skin becomes red and often swollen by the influx of these cytokines.<\/p>\n<p>That\u2019s temporary, beneficial, ACUTE inflammation.<\/p>\n<p>Normally, the inflammatory cells attack the bacteria or heal the damaged tissue and gradually this visible inflammation subsides. But sometimes your immune system doesn\u2019t do its job fully, and internal, invisible inflammation persists. You have CHRONIC inflammation.<\/p>\n<p>This harmful type of inflammation is a symptom of many chronic diseases, such as:<\/p>\n<ul>\n<li><strong><span style=\"color: #ff0000;\">&gt;<\/span><\/strong> Arthritis<\/li>\n<li><strong><span style=\"color: #ff0000;\">&gt; <\/span><\/strong>Alzheimer\u2019s disease<\/li>\n<li><strong><span style=\"color: #ff0000;\">&gt; <\/span><\/strong>Type 2 diabetes<\/li>\n<li><strong><span style=\"color: #ff0000;\">&gt; <\/span><\/strong>IBS<\/li>\n<li><strong><span style=\"color: #ff0000;\">&gt; <\/span><\/strong>Asthma<\/li>\n<\/ul>\n<p>And it sets up an environment where cancer can more easily spread, where mitochondria are damaged, dementia risk increases and heart disease develops.<\/p>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-medium wp-image-6116\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/11\/The-Results-Of-Inflammation-graphic-300x244.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"244\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/11\/The-Results-Of-Inflammation-graphic-300x244.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/11\/The-Results-Of-Inflammation-graphic-1030x839.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/11\/The-Results-Of-Inflammation-graphic-1500x1221.jpg 1500w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/11\/The-Results-Of-Inflammation-graphic-845x684.jpg 845w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/11\/The-Results-Of-Inflammation-graphic-705x574.jpg 705w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/11\/The-Results-Of-Inflammation-graphic-450x366.jpg 450w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>As mentioned, chronic inflammation is mostly undetectable \u2013 which makes it so dangerous. But occasionally it does manifest as fatigue, joint pain or skin rash \u2013 as in arthritis and psoriasis.<\/p>\n<p>Some lifestyle factors also contribute to inflammation in the body. They include:<\/p>\n<ul>\n<li><strong><span style=\"color: #ff0000;\">&gt; <\/span><\/strong>Drinking alcohol in excess \u2013 over 17 units a week<\/li>\n<li><strong><span style=\"color: #ff0000;\">&gt; <\/span><\/strong>Having a high body mass index (BMI) of over 30 \u2013 unless you are exceptionally muscular<\/li>\n<li><strong><span style=\"color: #ff0000;\">&gt; <\/span><\/strong>Lack of exercise<\/li>\n<li><strong><span style=\"color: #ff0000;\">&gt; <\/span><\/strong>Frequent stress<\/li>\n<\/ul>\n<p><u>Any process that reduces this chronic inflammation will have a positive effect on your health and will help slow ageing.<\/u><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14476-3\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14476-3-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14476-3-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3>Link between free radical damage and inflammation<\/h3>\n<p>Free radicals are unstable and highly reactive molecules that are produced in the body as a by-product of metabolism.<\/p>\n<p>Metabolism occurs when oxygen is \u2018burned\u2019 with fat or glucose to produce energy. So free radical damage is also called \u2018oxidative stress.\u2019 Some free radical production is natural and inevitable, but <em>excess<\/em> free radical production is the danger.<\/p>\n<p>Free radicals are also created by exposure to toxins in the environment, ultraviolet light (sunlight) and even some viruses.\u00a0 Free radicals have a lifespan of only a fraction of a second, but during that time they can damage DNA, potentially leading to cancer.<\/p>\n<p>Free radicals also damage cell membranes in the brain, the lining of arteries leading to heart disease, the lens of the eye leading to blindness, and proteins in the body. It is a \u2018rogue\u2019 protein called beta amyloid that characterises Alzheimer\u2019s.<\/p>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-medium wp-image-7188\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2017\/04\/free-radical-attack-HDF-300x162.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"162\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2017\/04\/free-radical-attack-HDF-300x162.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2017\/04\/free-radical-attack-HDF.jpg 375w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>So free radicals cause damage to cells and cellular damage triggers an immune response \u2013 and inflammation.<\/p>\n<p>This inflammation can fuel yet more free radicals in a vicious, inter-connected circle (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8221019\/\">Ref.<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8862535\/\">Ref.<\/a>).<\/p>\n<p>Therefore, cellular inflammation and free radical damage to cells are both linked and centrally important in ageing <a href=\"https:\/\/www.research.colostate.edu\/healthyagingcenter\/2020\/09\/17\/inflammaging-the-side-effect-of-age-you-havent-heard-of\/#:~:text=Aging%20is%20a%20complex%20process%2C%20and%20research%20suggests,is%20what%20scientists%20fittingly%20call%20%E2%80%9Cinflammaging%E2%80%9D%20%28Franceschi%202000%29.\">(Ref.).<\/a><\/p>\n<p>Which means that anti-inflammatory and antioxidant foods and nutritional supplements are an important part of a successful ageing strategy.<\/p>\n<p><u>Anti<\/u>oxidants in the foods we eat can neutralise free radicals, reducing the risk of oxidative damage. Examples of dietary antioxidants include vitamins A, C, E, beta-carotene, colour compounds called anthocyanidins in berries, Omega 3, a nutrient called EGCG in green tea, and many more.<\/p>\n<p>The body can also produce its own antioxidants which are more powerful than antioxidant supplements \u2013 and <a href=\"https:\/\/nutrishield.com\/switch-on-good-genes-for-longer-healthier-life\/\">in another article in this series\u00a0<\/a>we saw that turning on the Nrf2 gene could increase the body\u2019s natural antioxidant, glutathione.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14476-3-0-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"4\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3>An anti-inflammatory and therefore anti-ageing diet<\/h3>\n<p>There are \u2018hot spots\u2019 in certain parts of the world where far more people than usual live happy and disease-free lives, well into old age. Places with healthy centenarians. They are often called \u2018Blue Zones\u2019, a term coined by the researcher Dan Buettner. The lifestyle and diet of these centenarians are the key.<\/p>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-14481 size-full\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/blue-zones-SStk.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"1000\" height=\"625\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/blue-zones-SStk.jpg 1000w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/blue-zones-SStk-300x188.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/blue-zones-SStk-768x480.jpg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<p>So, it\u2019s no coincidence that the <strong>Mediterranean Diet<\/strong> and the <strong>Japanese Diet<\/strong> (and especially the Okinawan) are diets that increase health span. They are very high in anti-inflammatory and antioxidant nutrients.<\/p>\n<p>But we can do even better.<\/p>\n<p>Because there is a food plan called the <strong>DASH<\/strong> <strong>Diet<\/strong>. It stands for <strong>D<\/strong>ietary <strong>A<\/strong>pproaches to <strong>S<\/strong>top <strong>H<\/strong>ypertension.<\/p>\n<p>Studies confirm that DASH significantly lowers high blood pressure and improves levels of cholesterol, reducing your risk of heart disease, stroke and kidney failure (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9099655\/\">Ref.<\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25149893\/\">Ref.)<\/a><\/p>\n<p>There is also a food plan called the <strong>MIND<\/strong> <strong>Diet<\/strong> \u2013 a modification of the Mediterranean and DASH diet created by Rush University in the US. \u00a0Studies published in <em>The Journal of the Alzheimer\u2019s Association<\/em> (<a href=\"https:\/\/www.medicalnewstoday.com\/articles\/291073\">Ref.<\/a>) show the MIND Diet can averagely reduce the risk of cognitive decline and Alzheimer\u2019s by 54% and even a \u2018moderate adherence\u2019 produces a 35% reduction.<\/p>\n<p>Our <strong>\u2018Delay Ageing\u2019 Food Plan<\/strong> combines all these \u2013 the Mediterranean, Japanese, MIND and DASH diets \u2013 into a \u2018best of the best\u2019 plan.<\/p>\n<p>A study in 2022 (<a href=\"https:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.1003889\">Ref.<\/a>) showed that this type of combined plan can increase health span by over 8 years.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14476-3-0-2\" class=\"so-panel widget widget_sow-editor\" data-index=\"5\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2>Maintaining and improving immune function<\/h2>\n<p>A healthy immune system is vital in preventing infection, clearing residual inflammation, removing senescent cells, and in clearing pre-cancerous mutated cells.<\/p>\n<p>The pandemic has made T cells a rather well-known medical term. T cells, a type of white blood cell, mature in the <strong><u>t<\/u><\/strong>hymus. (T for thymus and thus T for T cells).<\/p>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-14483 size-medium\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/immune-cells-individual-AS-T-cell-241x300.jpeg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"241\" height=\"300\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/immune-cells-individual-AS-T-cell-241x300.jpeg 241w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/immune-cells-individual-AS-T-cell-828x1030.jpeg 828w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/immune-cells-individual-AS-T-cell-768x955.jpeg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/immune-cells-individual-AS-T-cell-1235x1536.jpeg 1235w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/immune-cells-individual-AS-T-cell-1647x2048.jpeg 1647w\" sizes=\"(max-width: 241px) 100vw, 241px\" \/><\/p>\n<p>T cells protect the body against cancerous cells and cells that have become infected by pathogens, such as bacteria and viruses.<\/p>\n<p>The problem is that the thymus (located just behind the breastbone) shrinks significantly over time, becomes \u2018fatty\u2019 and less effective \u2013 a process called <strong>immuno-senescence<\/strong>.<\/p>\n<p>This causes a decline in the production of new T cells and correlates with an increased risk of cancer. Even flu vaccines become less than 50% effective in people over 60 due to reduced T cells! (<a href=\"https:\/\/www.sciencedaily.com\/releases\/2016\/08\/160802103342.htm\">Ref.<\/a>)<\/p>\n<p>So counteracting a reduction in immune cell decline is yet another ageing factor to overcome.<\/p>\n<p>How? Extensive research confirms that the elements of the Delay Ageing Food and Lifestyle Plan powerfully support the immune system (<a href=\"https:\/\/www.health.harvard.edu\/staying-healthy\/crucial-ways-you-can-support-a-healthy-immune-system\">Ref.<\/a>)<\/p>\n<p>We also know that Vitamins A, C, D3 and E, together with zinc and selenium are vital immune support nutrients.<\/p>\n<p>As many as 42% of Americans are deficient in vitamin D3 (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21310306\/\">Ref.<\/a>) and the figure is similar in the UK.<\/p>\n<p>The latest research indicates that vitamin D3 at a level of 800 IU (International Units) a day in the summer and 2,000 IU in the winter appears optimum. <a href=\"https:\/\/nutrishield.com\/vitamin-d-cuts-the-risk-of-cancer\/\">How Vitamin D cuts the risk of cancer - NutriShield<\/a>. Vitamin D3 is a very inexpensive supplement and should be on everyone\u2019s supplement list.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14476-3-0-3\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"6\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3>The role of health supplements<\/h3>\n<h4><em><strong>Why a supplement?<\/strong><\/em><\/h4>\n<p>This graph illustrates the importance of defensive action. If you take action at point A, you can help avoid the typical path of disease when \u2018all-of-a-sudden\u2019 at point B you are diagnosed with a life-altering illness.<\/p>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-medium wp-image-14490\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/Optimal-health-to-disease-graph-300x208.png\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"208\" data-wp-editing=\"1\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/Optimal-health-to-disease-graph-300x208.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/Optimal-health-to-disease-graph-1030x714.png 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/Optimal-health-to-disease-graph-768x533.png 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/Optimal-health-to-disease-graph.png 1185w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>It wasn\u2019t \u2018all-of-a-sudden\u2019 \u2013 it was steadily developing for years. So, nowhere is the concept of <em>\u2018prevention is better than cure\u2019<\/em> more important than in health.<\/p>\n<p>I believe the first priority is <u>always<\/u> to get your nutrients from food \u2013 hence the <a href=\"https:\/\/nutrishield.com\/healthy-eating-and-lifestyle-plan-to-delay-ageing\/\">Delay Ageing Healthy Eating and Lifestyle Plan.<\/a><\/p>\n<p>Nevertheless, there are nutrients that may be present in your diet, but are rarely at a high enough level to counterbalance the multiple forces behind ageing. Forces that inexorably increase over the years.<\/p>\n<p>In addition, we know that people generally eat less as they get older and the ability to absorb nutrients from food does become less efficient over time \u2013 just as the demand for higher levels of preventative nutrition increases. (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK51837\/\">Ref.<\/a>)<\/p>\n<p>So, for all these reasons, I believe that nutrients that help slow ageing \u2013 and <u>therefore<\/u> increase healthy longevity and quality of life \u2013 should be increased in your diet via a health food <em>supplement<\/em>.<\/p>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-medium wp-image-14492\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/3-capsules-3-leaves-SStk-300x200.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"200\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/3-capsules-3-leaves-SStk-300x200.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/3-capsules-3-leaves-SStk-768x511.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/3-capsules-3-leaves-SStk-272x182.jpg 272w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/3-capsules-3-leaves-SStk.jpg 1000w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<h4><em><strong>What should be in an ideal anti-ageing supplement?<\/strong><\/em><\/h4>\n<p>Pulling together the conclusions from this five-part series these should include a range and optimum levels of nutrients that:<\/p>\n<ul>\n<li><strong><span style=\"color: #008000;\">&gt;<\/span> Act as anti-inflammatories<\/strong> \u2013 curcumin, green tea, bilberry, grapeseed<\/li>\n<li><strong><span style=\"color: #008000;\">&gt;<\/span> Are antioxidants<\/strong> \u2013 Omega 3, vitamins A, C, E, curcumin, green tea<\/li>\n<li><strong><span style=\"color: #008000;\">&gt;<\/span> Help repair DNA<\/strong> - resveratrol, curcumin, fisetin, vitamin C, B3 nicotinamide, beta carotene, lutein, lycopene.<\/li>\n<li><strong><span style=\"color: #008000;\">&gt;<\/span> Switch on beneficial genes<\/strong> (epigenetic modifiers) \u2013 folic acid, betaine, Omega 3, B12, curcumin, green tea, resveratrol, apigenin, lycopene, lutein, genistein<\/li>\n<li><strong><span style=\"color: #008000;\">&gt;<\/span> Support mitochondrial health and boost energy via NAD+<\/strong> \u2013 nicotinamide, CoQ10, Omega 3, curcumin, soy isoflavones, grapeseed, green tea, glucosamine<\/li>\n<li><strong><span style=\"color: #008000;\">&gt;<\/span> Help clear senescent cells<\/strong> \u2013 fisetin, grapeseed, curcumin, EGCG in green tea, glucosamine<\/li>\n<li><strong><span style=\"color: #008000;\">&gt;<\/span> Support the immune system<\/strong> \u2013 vitamins A, C, D3 and E, zinc and selenium<\/li>\n<\/ul>\n<p>This is <u>not<\/u> the definition of a simple one-a-day vitamin pill!<\/p>\n<p>Because delaying ageing, and the threats that accompany it, is <u>not<\/u> a simple process. So a <em>\u2018magic bullet\u2019<\/em> approach with a single ingredient is never going to work.<\/p>\n<p>It is the SYNERGY between multiple nutrients and lifestyle factors that makes the difference.<\/p>\n<p>Which is why we developed the supplement <strong>NutriShield<\/strong> which contains these elements: <a href=\"https:\/\/nutrishield.com\/\">NutriShield | Daily Nutritional Health Supplement from Uni-Vite Healthcare<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14476-4\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14476-4-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14476-4-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"7\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-13708 alignleft\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2021\/07\/Colin-Rose-300x300.png\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"100\" height=\"100\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/07\/Colin-Rose-300x300.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/07\/Colin-Rose-80x80.png 80w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/07\/Colin-Rose.png 500w\" sizes=\"(max-width: 100px) 100vw, 100px\" \/><\/p>\n<h3>Thanks for reading<\/h3>\n<p>I spend my time researching the new science of healthy, successful ageing. \u00a0And how to extend <em>health<\/em> span rather than just <em>life<\/em>span.<\/p>\n<p>I hope you got value from this part of the 5-part series. Links to the other 4 parts are:<\/p>\n<p style=\"padding-left: 40px;\"><a href=\"https:\/\/nutrishield.com\/protect-mitochondria-for-longer-healthier-life\/\">Longer Healthier Life Part 1: Protect Energy-Promoting Mitochondria<\/a><a href=\"https:\/\/nutrishield.com\/protecting-mitochondria-leads-to-longer-healthier-life\/\"><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-13839\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2021\/11\/nutrishieldreducefatigue-80x80.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"38\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/nutrishieldreducefatigue-300x188.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/nutrishieldreducefatigue.jpg 536w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\"><a href=\"https:\/\/nutrishield.com\/the-right-nutrients-protect-dna-for-longer-healthier-life\/\">Longer Healthier Life Part 2: The Right Nutrients Can Protect Your DNA<\/a><a href=\"https:\/\/nutrishield.com\/the-right-nutrients-can-protect-your-dna\/\"><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-14430\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/DNA-broken-SStk-80x80.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"34\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/DNA-broken-SStk-300x169.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/DNA-broken-SStk-768x432.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/DNA-broken-SStk.jpg 1000w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\"><a href=\"https:\/\/nutrishield.com\/clear-zombie-cells-for-longer-healthier-life\/\">Longer Healthier Life Part 3: Clear Zombie Cells to Stay Health<\/a><a href=\"https:\/\/nutrishield.com\/clear-zombie-cells-to-stay-healthy\/\"><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-14437\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk-80x80.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"40\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk-300x200.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk-768x512.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk-272x182.jpg 272w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/zombie-cell-SStk.jpg 1000w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><\/a>y<\/p>\n<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\"><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-14461\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/09\/dna-gene-80x80.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"33\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/dna-gene-300x164.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/dna-gene-768x419.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/09\/dna-gene.jpg 998w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><a href=\"https:\/\/nutrishield.com\/switch-on-good-genes-for-longer-healthier-life\/\">Longer Healthier Life Part 4: Switching On Good Protective Genes<\/a><\/p>\n<p>&nbsp;<\/p>\n<p style=\"padding-left: 40px;\"><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-13847\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield-80x80.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"60\" height=\"33\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield-300x166.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield-1030x571.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield-768x425.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/11\/immunesystemnutrishield.jpg 1379w\" sizes=\"(max-width: 60px) 100vw, 60px\" \/><a href=\"https:\/\/nutrishield.com\/defeat-inflammation-and-boost-immune-system-for-longer-healthier-life\/\">Longer Healthier Life Part 5: Defeating Inflammation and Boosting Your Immune System<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>And if you enjoyed it, please send the link of <strong>this article<\/strong> to any friend or family member who might benefit.<\/p>\n<p><em>Colin Rose<\/em><\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14476-4-0-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"8\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><!-- wp:image {\"id\":8961,\"align\":\"center\",\"linkDestination\":\"custom\"} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:html --><\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<h2>NutriShield Premium Health Supplement<\/h2>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-14200 size-large\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L-1030x564.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"1030\" height=\"564\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L-1030x564.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L-300x164.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L-768x420.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2022\/04\/NutriShield-Premium-30-day-pack-v11-1-Capsules-L.jpg 1200w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/>NutriShield Premium was originally designed by Dr Paul Clayton, former Chair of the Forum on Food and Health at the Royal Society of Medicine.<\/p>\n<p>It contains 6 different capsules, combining a total of 43 powerful nutrients to support healthy ageing and has been updated and improved every year since 2002 based on the newest longevity research.<\/p>\n<p><a href=\"http:\/\/nutrishield.com\">See NutriShield Premium here.<\/a><\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14476-4-0-2\" class=\"so-panel widget widget_sow-editor\" data-index=\"9\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><!-- wp:image {\"id\":8961,\"align\":\"center\",\"linkDestination\":\"custom\"} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:html --><\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:heading {\"level\":3} --><\/p>\n<h3><em>Delay Ageing<\/em> book explains the ageing process and how you can postpone it<\/h3>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-10523 size-medium alignleft\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-300x300.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"300\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-300x300.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-1030x1030.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-80x80.jpg 80w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-768x768.jpg 768w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D-1536x1536.jpg 1536w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2020\/10\/Delay-Ageing-book-3D.jpg 2000w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Medical researchers agree that if you slow ageing, you also delay the onset of age-related disease. And we know that it\u2019s not just nutrition. Sleep, reducing stress and cardio and strength exercise are also essential to longevity and ageing well.<\/p>\n<p>My book <em>Delay Ageing: Healthy to 100<\/em>, published in 2020, explains the latest ageing science in an accessible way.<\/p>\n<p>It\u2019s been rated 5-star and I am sure you will get a lot of benefit from it, as so many have already.<\/p>\n<p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/acceleratedlearning.com\/learning\/range\/books\/delay-ageing-book\">Click here to go to the publisher's website where you can buy the printed book or Kindle version.<\/a><\/span><\/p>\n<p><!-- \/wp:heading --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14476-4-0-3\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"10\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><!-- wp:image {\"id\":8961,\"align\":\"center\",\"linkDestination\":\"custom\"} --><\/p>\n<p><!-- \/wp:image --><!-- wp:separator --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:image {\"id\":8512,\"align\":\"center\"} --><\/p>\n<p>&nbsp;<\/p>\n<p><!-- \/wp:paragraph --><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:separator --><\/p>\n<hr class=\"wp-block-separator\" \/>\n<p><!-- \/wp:separator --><!-- wp:heading {\"level\":4} --><\/p>\n<figure><a title=\"Register for free e-newsletters\" href=\"https:\/\/nutrishield.com\/newsletters\/\"><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-4565 aligncenter\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"200\" height=\"71\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-495x177.png 495w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-450x159.png 450w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter.png 500w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/><\/a><\/figure>\n<h4>And register now for a free e-newsletter on the latest in nutrition and health research.<\/h4>\n<p><!-- \/wp:heading --><!-- wp:separator --><\/p>\n<hr \/>\n<p><img  title=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-10944 size-full\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2021\/03\/Uni-VIte-supplements.jpg\"  alt=\"Defeat inflammation and boost the immune system for longer healthier life NutriShield Multi Vitamins and Minerals\"  width=\"1030\" height=\"302\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/03\/Uni-VIte-supplements.jpg 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/03\/Uni-VIte-supplements-300x88.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2021\/03\/Uni-VIte-supplements-768x225.jpg 768w\" sizes=\"(max-width: 1030px) 100vw, 1030px\" \/><\/p>\n<p><a href=\"https:\/\/uni-vite.com\/supplements\">You can buy our range of combination anti-ageing, anti-inflammatory and immune-supporting health supplements online from Uni-Vite, a UK company.<\/a><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:separator --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:separator --><\/p>\n<p><!-- \/wp:paragraph --><!-- wp:separator --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14476-5\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-14476-5-0\"  class=\"panel-grid-cell\" ><div id=\"panel-14476-5-0-0\" class=\"so-panel widget widget_sow-accordion panel-first-child panel-last-child\" data-index=\"11\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-accordion so-widget-sow-accordion-default-2b55ed2807e6-14476\"\n\t\t\t\n\t\t><h3 class=\"widget-title\">REFERENCES<\/h3><div>\n\t<div class=\"sow-accordion\">\n\t\t\t<div class=\"sow-accordion-panel\"\n\t\t\t data-anchor=\"links-for-5-part-series-on-a-longer-healthier-life\">\n\t\t\t\t<div class=\"sow-accordion-panel-header-container\" role=\"heading\" aria-level=\"2\">\n\t\t\t\t\t<div class=\"sow-accordion-panel-header\" tabindex=\"0\" role=\"button\" id=\"accordion-label-links-for-5-part-series-on-a-longer-healthier-life\" aria-controls=\"accordion-content-links-for-5-part-series-on-a-longer-healthier-life\" aria-expanded=\"false\">\n\t\t\t\t\t\t<div class=\"sow-accordion-title sow-accordion-title-icon-left\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\tLinks for 5-part series on A Longer Healthier Life\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"sow-accordion-open-close-button\">\n\t\t\t\t\t\t\t<div class=\"sow-accordion-open-button\">\n\t\t\t\t\t\t\t\t<span class=\"sow-icon-ionicons\" data-sow-icon=\"&#xf218;\"\n\t\t \n\t\taria-hidden=\"true\"><\/span>\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"sow-accordion-close-button\">\n\t\t\t\t\t\t\t\t<span class=\"sow-icon-ionicons\" data-sow-icon=\"&#xf209;\"\n\t\t \n\t\taria-hidden=\"true\"><\/span>\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\n\t\t\t<div\n\t\t\t\tclass=\"sow-accordion-panel-content\"\n\t\t\t\trole=\"region\"\n\t\t\t\taria-labelledby=\"accordion-label-links-for-5-part-series-on-a-longer-healthier-life\"\n\t\t\t\tid=\"accordion-content-links-for-5-part-series-on-a-longer-healthier-life\"\n\t\t\t\tstyle=\"display: none;\"\t\t\t>\n\t\t\t\t<div class=\"sow-accordion-panel-border\" tabindex=\"0\">\n\t\t\t\t\t<p><strong>THEORIES OF AGEING<\/strong><\/p>\n<p><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(13)00645-4\">The Hallmarks of Aging: Cell<\/a><\/p>\n<p><a href=\"https:\/\/www.ft.com\/content\/24849908-ac4a-4a7d-b53c-847963ac1228\">Silicon Valley\u2019s billionaires want to hack the ageing process | Financial Times (ft.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19149749\/\">Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.kurzweilai.net\/how-to-prevent-a-global-aging-crisis#!prettyPhoto\">How to Prevent a Global Aging Crisis \u00ab Kurzweil (kurzweilai.net)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34488874\/#:~:text=Cellular%20reprogramming%20and%20epigenetic%20rejuvenation%20Ageing%20is%20an,and%20reversing%20the%20ageing%20process%20might%20be%20possible.\">Cellular reprogramming and epigenetic rejuvenation - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2995895\/\">Modern Biological Theories of Aging (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25519063\/\">Modern evolutionary mechanics theories and resolving the programmed\/non-programmed aging controversy - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25902456\/\">Is the Evolutionary Programmed\/ Non-programmed Aging Argument Moot? - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0531556502001614\">A Darwinian-evolutionary concept of age-related diseases - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6842891\/\">Vascular Aging: Healthy lifestyle-based approaches for successful vascular aging - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3640494\/\">Transcriptional Regulation and its Misregulation in Disease - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0167779922000257#:~:text=Regardless%2C%20reprogramming%20can%20reset%20epigenetic%20age%20to%20zero,at%20least%20at%20some%20level%2C%20a%20rejuvenation%20procedure.\">Cellular reprogramming and the rise of rejuvenation biotech - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/www.academicgates.com\/news\/story\/food-pattern-calculator-estimates-how-to-gain-up-to-ten-life-years\/10183#:~:text=A%20study%20published%20in%20PLOS%20Medicine%20on%20the,you%20could%20gain%20by%20modifications%20in%20diet%20patterns.\">Food pattern calculator estimates how to gain up to ten life years - Academic Gates<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s43587-021-00080-0?code=5279c64f-f92f-4c77-88dd-1c45d7daf3ae\">The economic value of targeting aging | Nature Aging<\/a><\/p>\n<p><a href=\"https:\/\/www.sanger.ac.uk\/news_item\/cellular-secrets-of-ageing-unlocked-by-researchers\/\">Cellular secrets of ageing unlocked by researchers \u2013 Wellcome Sanger Institute<\/a><\/p>\n<p><a href=\"https:\/\/journals.plos.org\/plosmedicine\/article?id=10.1371\/journal.pmed.0050012\">Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study | PLOS Medicine<\/a><\/p>\n<p><a href=\"https:\/\/www.nia.nih.gov\/news\/biology-aging-study-shows-why-curbing-calories-counts\">Biology of aging study shows why curbing calories counts | National Institute on Aging (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34532416\/\">Pluripotent stem cell therapy for retinal diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/ajcn\/article\/114\/4\/1447\/6301120?login=false\">Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort | The American Journal of Clinical Nutrition | Oxford Academic (oup.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.scholars.northwestern.edu\/en\/publications\/dietary-factors-gut-microbiota-and-serum-trimethylamine-n-oxide-a\">Dietary factors, gut microbiota, and serum trimethylamine-N-oxide associated with cardiovascular disease in the Hispanic Community Health Study\/Study of Latinos \u2014 Northwestern Scholars<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30112360\/\">Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer's Disease - PubMed (nih.gov)<\/a><\/p>\n<hr \/>\n<p><strong>NUTRIENT RESEARCH <\/strong><\/p>\n<p><strong>MULTI-NUTRIENT STUDIES<\/strong><\/p>\n<p><a href=\"https:\/\/www.clinicalnutritionjournal.com\/article\/S0261-5614(21)00553-7\/fulltext\">Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial - Clinical Nutrition (clinicalnutritionjournal.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3276397\/\">Influence of Dietary Components on Regulatory T Cells (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.apjtb.org\/article.asp?issn=2221-1691;year=2018;volume=8;issue=2;spage=120;epage=129;aulast=Sabahi\">Insight into DNA protection ability of medicinal herbs and potential mechanisms in hydrogen peroxide damages model Sabahi Z, Soltani F, Moein M - Asian Pac J Trop Biomed (apjtb.org)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22362552\/\">Effects of micronutrients on DNA repair - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33995644\/\">Phytochemicals in Chemoprevention: A Cost-Effective Complementary Approach - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18568016\/\">Brain foods: the effects of nutrients on brain function - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31077707\/\">Emerging senolytic agents derived from natural products - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8429479\/\">Lifestyle Adjustments in Long-COVID Management: Potential Benefits of Plant-Based Diets (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4566449\/\">Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/hmbci-2016-0034\/html\">Nutritional regulation of fibroblast growth factor 21: from macronutrients to bioactive dietary compounds (degruyter.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8445631\/\">The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/cosmostrial.org\/results\/\">COcoa Supplement and Multivitamin Outcomes Study<\/a><\/p>\n<hr \/>\n<p><strong>INDIVIDUAL NUTRIENT STUDIES<\/strong><\/p>\n<p><strong>APIGENIN<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3609577\/\">Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/apigenin\">Apigenin - an overview | ScienceDirect Topics<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6472148\/\">The Therapeutic Potential of Apigenin (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6817918\/\">A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10751547\/\">Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0104321#:~:text=Apigenin%20and%20luteolin%20were%20identified%20in%20our%20U-2,of%20FOXO1%20as%20shown%20by%20live%20cell%20imaging.\">The Flavones Apigenin and Luteolin Induce FOXO1 Translocation but Inhibit Gluconeogenic and Lipogenic Gene Expression in Human Cells (plos.org)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22098587\/\">Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells - PubMed (nih.gov)<\/a><\/p>\n<p><strong>CAROTENOIDS<\/strong><strong> (includes Lutein, Lycopene)<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14748939\/\">Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/academic.oup.com\/jn\/article\/135\/8\/2071S\/4664044\">How Strong Is the Evidence that Lycopene Supplementation Can Modify Biomarkers of Oxidative Damage and DNA Repair in Human Lymphocytes? | The Journal of Nutrition | Oxford Academic (oup.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5715043\/\">Dietary guidance for lutein: consideration for intake recommendations is scientifically supported (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK225469\/\">\u03b2-Carotene and Other Carotenoids - Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids - NCBI Bookshelf (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8815648\/\">[Daily intake of carotenoids (carotenes and xanthophylls) from total diet and the carotenoid content of selected vegetables and fuit] - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14748939\/\">Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes - PubMed (nih.gov)<\/a><\/p>\n<p><strong>CO-ENZYME Q10<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22885103\/\">Coenzyme Q10 increases the fatty acid oxidation through AMPK-mediated PPAR\u03b1 induction in 3T3-L1 preadipocytes - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17914161\/\">Bioenergetic and antioxidant properties of coenzyme Q10: recent developments - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24170646\/\">Statins' effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29766349\/\">Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34959985\/\">Nutrients to Improve Mitochondrial Function to Reduce Brain Energy Deficit and Oxidative Stress in Migraine - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9266531\/\">Coenzyme Q10 in the diet--daily intake and relative bioavailability - PubMed (nih.gov)<\/a><\/p>\n<p><strong>CURCUMIN\/TURMERIC<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5664031\/\">Curcumin: A Review of Its Effects on Human Health (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7144558\/\">Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31580521\/\">Effects of curcumin on mitochondria in neurodegenerative diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.bbc.co.uk\/programmes\/articles\/PSTGKKt3HR08tmK69w7J1b\/does-turmeric-really-help-protect-us-from-cancer\">BBC Two - Trust Me, I'm a Doctor, Series 5, Episode 3 - Does turmeric really help protect us from cancer?<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15650394\/\">Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28799796\/\">Immune modulation by curcumin: The role of interleukin-10 - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19665995\/#:~:text=Curcumin%20activates%20AMPK%20and%20suppresses%20gluconeogenic%20gene%20expression,related%20structures%20possess%20potent%20anti-oxidant%20and%20anti-inflammatory%20properties.\">Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27967217\/\">Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6518239\/\">Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro - PMC (nih.gov)<\/a><\/p>\n<p><strong>FISETIN<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21738623\/\">Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6572624\/\">Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3689181\/\">Fisetin: A Dietary Antioxidant for Health Promotion (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/mayoclinic.pure.elsevier.com\/en\/publications\/fisetin-is-a-senotherapeutic-that-extends-health-and-lifespan\">Fisetin is a senotherapeutic that extends health and lifespan \u2014 Mayo Clinic (elsevier.com)<\/a><\/p>\n<p><strong>GLUCOSAMINE<\/strong><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/ncomms4563\">D-Glucosamine supplementation extends life span of nematodes and of ageing mice | Nature Communications<\/a><\/p>\n<p><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jag\/65\/3\/65_jag.JAG-2018_002\/_html\/-char\/en\">Glucosamine Extends the Lifespan of Caenorhabditis elegans via Autophagy Induction (jst.go.jp)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24444050\/\">Assessment of protective effects of glucosamine and N-acetyl glucosamine against DNA damage induced by hydrogen peroxide in human lymphocytes - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3772083\/\">Glucosamine Activates Autophagy In Vitro and In Vivo (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3557824\/\">Use of Glucosamine and Chondroitin in Relation to Mortality (nih.gov)<\/a><\/p>\n<p><strong>LUTEOLIN<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2615542\/\">Luteolin, a flavonoid with potentials for cancer prevention and therapy (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5635727\/\">Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33522240\/\">Dietary Luteolin: A Narrative Review Focusing on Its Pharmacokinetic Properties and Effects on Glycolipid Metabolism - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27377953\/#:~:text=Further%2C%20luteolin%20treatment%20directly%20elevated%20thermogenic%20gene%20expressions,browning%20and%20thermogenesis%20through%20an%20AMPK%2FPGC1%CE%B1%20pathway-mediated%20mechanism.\">Dietary luteolin activates browning and thermogenesis in mice through an AMPK\/PGC1\u03b1 pathway-mediated mechanism - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21468539\/\">Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-\u03baB modulation in HepG2 hepatocarcinoma cells - PubMed (nih.gov)<\/a><\/p>\n<p><strong>NICOTINAMIDE\/NIACIN (Vitamin B3)<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11126400\/\">Safety of high-dose nicotinamide: a review - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33196157\/\">Nicotinamide: An Update and Review of Safety &amp; Differences from Niacin - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3208503\/\">The role of PARP in DNA repair and its therapeutic exploitation (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18429699\/\">Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7226615\/\">Nicotinamide, Nicotinamide Riboside and Nicotinic Acid\u2014Emerging Roles in Replicative and Chronological Aging in Yeast (nih.gov)<\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7226615\/\">Nicotinamide, Nicotinamide Riboside and Nicotinic Acid\u2014Emerging Roles in Replicative and Chronological Aging in Yeast (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7277745\/\">Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-019-46678-8\">Nicotinamide Augments the Anti-Inflammatory Properties of Resveratrol through PARP1 Activation | Scientific Reports (nature.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27127236\/\">NAD\u207a repletion improves mitochondrial and stem cell function and enhances life span in mice - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32386566\/\">Niacin Cures Systemic NAD + Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32903806\/\">Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease \u2013 PubMed<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-018-03421-7\">Chronic\u00a0nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults | Nature Communications<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8841834\/\">The effect of niacinamide on osteoarthritis: a pilot study - PubMed (nih.gov)<\/a><\/p>\n<p><strong>OMEGA 3<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31242648\/\">Omega-3 Fatty Acids-Enriched Fish Oil Activates AMPK\/PGC-1\u03b1 Signaling and Prevents Obesity-Related Skeletal Muscle Wasting - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3545053\/\">Omega-3 Fatty Acids, Oxidative Stress, and Leukocyte Telomere Length: A Randomized Controlled Trial (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24396061\/\">Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22332096\/\">Omega-3 fatty acids EPA and DHA: health benefits throughout life - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2451847619300387#:~:text=The%20current%20study%20has%20shown%20that%20omega-3%20fatty,decrease%20gene%20expression%20of%20UCP-2%20in%20CAD%20patients.\">Omega-3 fatty acids and vitamin E supplementation can affect gene expressions of SIRT1, FOXO1 and UCP-2 in coronary artery disease patients - ScienceDirect<\/a><\/p>\n<p><strong>POLYPHENOLS, FLAVONOIDS AND OTHER PHYTOCHEMICALS<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31412639\/\">Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24875147\/\">Polyphenols and mitochondria: an update on their increasingly emerging ROS-scavenging independent actions - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.mdpi.com\/1422-0067\/20\/20\/5090\"><u>Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer\u2019s Disease (nih.gov)<\/u> Disease (mdpi.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29703769\/\">Pattern of polyphenol intake and the long-term risk of dementia in older persons - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26325006\/\">Flavonol Intake and Cognitive Decline in Middle-Aged Adults - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5841289\/\">Natural polyphenols as sirtuin 6 modulators (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22535616\/\">Dietary intakes of berries and flavonoids in relation to cognitive decline - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/content.iospress.com\/articles\/nutrition-and-aging\/nua0051*\">Protective effects of berry polyphenols against age-related cognitive impairment - IOS Press<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27443888\/\">Potentiation of the bioavailability of blueberry phenolic compounds by co-ingested grape phenolic compounds in mice, revealed by targeted metabolomic profiling in plasma and feces - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30032176\/\">Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29854398\/\">Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6266803\/\">The Immunomodulatory and Anti-Inflammatory Role of Polyphenols (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2852857\/\">Biological Activities of Polyphenols from Grapes (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23840922\/\">Polyphenols: multipotent therapeutic agents in neurodegenerative diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30551400\/\">Phytochemicals and cognitive health: Are flavonoids doing the trick? - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20955649\/\">The impact of fruit flavonoids on memory and cognition - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31329250\/\">Recent Research on the Health Benefits of Blueberries and Their Anthocyanins - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33466731\/\">Blueberry Supplementation in Neuronal Health and Protective Technologies for Efficient Delivery of Blueberry Anthocyanins - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7480644\/\">Potential use of polyphenols in the battle against COVID-19 (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32720577\/\">Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34946521\/\">Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp) - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6627994\/\">Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern? (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128018163000467\">Polyphenols and Aging - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6115785\/\">Effects of Polyphenol-Rich Foods on Human Health - PMC (nih.gov)<\/a> .<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29703769\/\">Pattern of polyphenol intake and the long-term risk of dementia in older persons - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6133707\/\">Dietary polyphenols promote resilience against sleep deprivation\u2013induced cognitive impairment by activating protein translation (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0960894X11006512\">Flavonoids as inhibitors of human CD38 - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/europepmc.org\/article\/PMC\/PMC4840337\">Dietary proanthocyanidins boost hepatic NAD(+) metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats. - Abstract - Europe PMC<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7504512\/\">Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/journals.lww.com\/neuroreport\/Fulltext\/2020\/08020\/Tea_polyphenols_protect_learning_and_memory_in.2.aspx\">Tea polyphenols protect learning and memory in sleep-deprived mice : NeuroReport (lww.com)<\/a><\/p>\n<p><a href=\"https:\/\/moh-it.pure.elsevier.com\/en\/publications\/specific-dietary-polyphenols-are-associated-with-sleep-quality-in\">Specific dietary (Poly)phenols are associated with sleep quality in a cohort of Italian adults \u2014 Italian Ministry of Health (elsevier.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5613902\/\">Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/europepmc.org\/article\/PMC\/PMC6405770\">Green tea extract promotes DNA repair in a yeast model. - Abstract - Europe PMC<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21641214\/\">Flavonoids as inhibitors of human CD38 - PubMed (nih.gov)<\/a><\/p>\n<p><strong>PTEROSTILBENE AND RESVERATROL<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21982274\/\">Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29210129\/\">Effect of resveratrol and pterostilbene on aging and longevity - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30484255\/\">Resveratrol and 1,25-dihydroxyvitamin D co-administration protects the heart against D-galactose-induced aging in rats: evaluation of serum and cardiac levels of klotho - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2899944\/\">Dietary intake of pterostilbene, a constituent of blueberries, inhibits the \u03b2-catenin\/p65 downstream signaling pathway and colon carcinogenesis in rats (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3699815\/\">Resveratrol-Activated AMPK\/SIRT1\/Autophagy in Cellular Models of Parkinson's Disease (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25669932\/\">The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29210129\/\">Effect of resveratrol and pterostilbene on aging and longevity - PubMed (nih.gov)<\/a><\/p>\n<p><strong>QUERCETIN<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4808895\/\">Quercetin, Inflammation and Immunity (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8109056\/\">Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29864946\/#:~:text=Quercetin%20not%20only%20enhanced%20mitochondrial%20membrane%20potential%2C%20oxygen,%28MMP%29-3%29%20and%20MMP-13%20could%20be%20suppressed%20by%20quercetin.\">Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK\/SIRT1 signaling pathway in OA rats - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6572624\/\">Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33860002\/\">Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases - PubMed (nih.gov)<\/a><\/p>\n<p><strong>SEAWEED<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28635652\/\">Fucaceae: A Source of Bioactive Phlorotannins - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B978012813312500011X#:~:text=Recent%20studies%20have%20demonstrated%20a%20variety%20of%20health-benefitting,including%20anticoagulant%2C%20antitumor%2C%20antithrombosis%2C%20antivirus%2C%20antioxidation%2C%20and%20immunomodulation.\">Fucoidan and Its Health Benefits - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/d1wqtxts1xzle7.cloudfront.net\/44159778\/Phlorotannins_of_the_edible_brown_seawee20160328-28027-nli846-with-cover-page-v2.pdf?Expires=1647609336&amp;Signature=JOx8Du18boeRDOey0zKiPfw1xAvrwulwfZNueu--eUO0fA4mFCJaqcbDKAr2sgLINpeLBwNYuhGhgMy5rpWhsMWK1SvYStjSzlekGOpbRdPUJKDWOdDkONZlQiRfxlgx9BBjaSsXUWCItYO9W97MTblsCB3rhEugISqb7WbajrvUoYEzTyBLayOJVjnkRszzp9VYxjh29uyDy0FSWm5gRXlupPIjXabt4tUUmHox8zM40mk2H665RBnO-v~ZRbYzHi7te68KMiDOgXOG8I2w4sqLKEjuNL8BjZZ9u1DXAIk85-9tUQG1HPI5PbOA5uOoPk8Xfddp-7RtxA2gTS4s3A__&amp;Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA\">Phlorotannins_of_the_edible_brown_seawee20160328-28027-nli846-with-cover-page-v2.pdf (d1wqtxts1xzle7.cloudfront.net)<\/a><\/p>\n<p><a href=\"https:\/\/neuro.unboundmedicine.com\/medline\/citation\/28635652\/Fucaceae:_A_Source_of_Bioactive_Phlorotannins_\">PRIME PubMed | Fucaceae: A Source of Bioactive Phlorotannins (unboundmedicine.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25026264\/\">Ascophyllan purified from Ascophyllum nodosum induces Th1 and Tc1 immune responses by promoting dendritic cell maturation - PubMed (nih.gov)<\/a><\/p>\n<p><strong>VITAMIN D<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30256915\/\">Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4399494\/\">The Role of Vitamin D in the Aging Adult (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33415918\/\">Vitamin D: a Review of its Effects on Epigenetics and Gene Regulation - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3166406\/#:~:text=These%20effects%20result%20in%20decreased%20production%20of%20inflammatory,such%20as%20IL-1%2C%20IL-6%2C%20IL-8%2C%20IL-12%20and%20TNF%CE%B1.\">Vitamin D and the Immune System (nih.gov)<\/a><\/p>\n<p><strong>OTHER INDIVIDUAL NUTRIENTS<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26092624\/\">Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer's Disease - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.researchgate.net\/publication\/358202764_A_Potential_Probiotic_Lactobacillus_plantarum_JBC5_Improves_Longevity_and_Healthy_Aging_by_Modulating_Antioxidative_Innate_Immunity_and_Serotonin-Signaling_Pathways_in_Caenorhabditis_elegans\">(PDF) A Potential Probiotic Lactobacillus plantarum JBC5 Improves Longevity and Healthy Aging by Modulating Antioxidative, Innate Immunity and Serotonin-Signaling Pathways in Caenorhabditis elegans (researchgate.net)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC64728\/\">Chlorophyllin intervention reduces aflatoxin\u2013DNA adducts in individuals at high risk for liver cancer (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.oncologynutrition.org\/erfc\/healthy-nutrition-now\/folate-and-cancer#:~:text=The%20association%20of%20folate%20to%20cancer%20is%20sometimes,or%20too%20much%20folate%20may%20contribute%20to%20cancer.\">Folate and Cancer - Oncology Nutrition DPG<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34030963\/\">Impact of the Natural Compound Urolithin A on Health, Disease, and Aging - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6128428\/\">Spermidine delays aging in humans (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6683102\/#:~:text=Numerous%20studies%20have%20suggested%20that%20soy%20isoflavones%20provide,associated%20with%20the%20menopause%20%5B%206%2C%207%20%5D.\">Biological Effect of Soy Isoflavones in the Prevention of Civilization Diseases - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5024025\/\">Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4749867\/\">The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer's Disease - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s42255-021-00491-8\">The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice | Nature Metabolism<\/a><\/p>\n<hr \/>\n<p><strong>BODY CELLS AND PROCESSES<\/strong><\/p>\n<p><strong>ALPHA-KETOGLUTARATE<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4703346\/\">Alpha-Ketoglutarate: Physiological Functions and Applications (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32877690\/\">Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5274648\/\">Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use (nih.gov)<\/a><\/p>\n<p><strong>GENES AND GENETICS<\/strong><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/ejhg2013299\">Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis | European Journal of Human Genetics (nature.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/sites\/ppmc\/articles\/PMC3336960\/\">Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ndph.ox.ac.uk\/news\/genetic-study-provides-new-evidence-that-alcohol-accelerates-biological-aging\">Genetic study provides new evidence that alcohol accelerates biological ageing \u2014 Nuffield Department of Population Health (ox.ac.uk)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18344981\/\">Genetics of gene expression and its effect on disease - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352154621001613\">Epigenetic protection: maternal touch and DNA-methylation in early life - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21716585\/#:~:text=The%20klotho%20gene%20was%20originally%20identified%20as%20a,goddess%20Klotho%20who%20spun%20the%20thread%20of%20life.\">Klotho and the aging process - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24124751\/\">Significance of the anti-aging protein Klotho - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26827953\/\">1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4783344\/\">Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5403515\/\">FOXO3 \u2013 A Major Gene for Human Longevity (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2021.746631\/full\">Frontiers | Sirtuins as Potential Therapeutic Targets for Mitigating Neuroinflammation Associated With Alzheimer\u2019s Disease | Cellular Neuroscience (frontiersin.org)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3620486\/\">The role of sirtuins in Alzheimer's disease - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22436748\/\">AMPK: a nutrient and energy sensor that maintains energy homeostasis - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21031035\/\">Nrf2, a guardian of healthspan and gatekeeper of species longevity - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7711617\/#:~:text=Nrf2-interacting%20nutrients%20The%20most%20common%20Nrf2%20nutrients%20include,fruits%2C%20and%20Lactobacillus%20in%20fermented%20foods%20%28Table%201%29.\">Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16522169\/\">Nutraceuticals synergistically promote proliferation of human stem cells - PubMed (nih.gov)<\/a><\/p>\n<p><strong>GLYCATION AND AGEs<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5643203\/\">The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9777946\/\">Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27373680\/\">Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential contributions to disease - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28096127\/\">Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases - PubMed (nih.gov)<\/a><\/p>\n<p><strong>LITHIUM<\/strong><\/p>\n<p><a href=\"https:\/\/www.medicalnewstoday.com\/articles\/308830#:~:text=Lithium%20blocks%20GSK-3%20to%20increase%20lifespan.%20What%20is,-%20a%20key%20player%20in%20the%20aging%20process.\">Lithium brings anti-aging drugs a step closer (medicalnewstoday.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41380-018-0024-6\">Lithium treatment and mechanisms of aging | Molecular Psychiatry (nature.com)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21301855\/\">Low-dose lithium uptake promotes longevity in humans and metazoans - PubMed (nih.gov)<\/a><\/p>\n<p><strong>METHYLATION AND METHYL DONORS<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6471069\/\">Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/biomedres.us\/fulltexts\/BJSTR.MS.ID.002893.php\">The potential of nutritional supplements: methyl donor rich food and their application in oncology (biomedres.us)<\/a><\/p>\n<p><a href=\"https:\/\/www.linkedin.com\/pulse\/role-methylation-adaptogens-dr-alexander-jimenez-\/\">(99+) The Role of Methylation Adaptogens | LinkedIn<\/a><\/p>\n<p><a href=\"https:\/\/pdfs.semanticscholar.org\/382c\/dd8b2e68f3947ff9ef286dc9b6fb3a42552e.pdf\">Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome (semanticscholar.org)<\/a><\/p>\n<p><strong>NAD+<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5088772\/\">Why NAD+ Declines during Aging: It\u2019s Destroyed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5034109\/\">Restoring stem cells \u2014 all you need is NAD+ - PMC (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/acel.12935\">NAD+ supplementation rejuvenates aged gut adult stem cells - Igarashi -2019 - Aging Cell - Wiley Online Library<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s43587-022-00174-3#:~:text=Furthermore%2C%20we%20found%20that%20in%20the%20older%20adults%2C,with%20the%20healthy%20aging%20state%20of%20the%20individual.\">Healthy aging and muscle function are positively associated with NAD+ abundance in humans | Nature Aging<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27304496\/\">Why NAD(+) Declines during Aging: It's Destroyed - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27825999\/\">NAD and the aging process: Role in life, death and everything in between - PubMed (nih.gov)<\/a><\/p>\n<p><strong>SIRTUINS<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5514220\/#:~:text=One%20of%20the%20most%20promising%20targets%20for%20anti-ageing,to%20occur%20in%20bacteria%20and%20eukaryotes%20%28including%20mammals%29.\">Sirtuins, a promising target in slowing down the ageing process (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7426493\/\">SIRT1 Activation by Natural Phytochemicals: An Overview (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.cell.com\/trends\/cell-biology\/pdf\/S0962-8924(21)00125-2.pdf\">Sirtuin 6: linking longevity with genome and epigenome stability (cell.com)<\/a><\/p>\n<p><strong>TELOMERES<\/strong><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0140673603123847\">Association between telomere length in blood and mortality in people aged 60 years or older - ScienceDirect<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19279081\/\">Multivitamin use and telomere length in women - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26839872\/\">Leukocyte Telomere Length is Associated With Serum Vitamin B12 and Homocysteine Levels in Older Adults With the Presence of Systemic Inflammation - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25803084\/\">The role of telomeres and vitamin D in cellular aging and age-related diseases - PubMed (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.semanticscholar.org\/paper\/Age-dependent-telomere-shortening-is-slowed-down-by-Furumoto-Inoue\/c0cc30badf0edd9b5b5056db90ac9d26cbf5b5b7\">[PDF] Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. | Semantic Scholar<\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4234001\/\">Association Between Higher Plasma Lutein, Zeaxanthin, and Vitamin C Concentrations and Longer Telomere Length: Results of the Austrian Stroke Prevention Study (nih.gov)<\/a><\/p>\n<p><strong>OTHER<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3410706\/#:~:text=Interleukin%2010%20%28IL-10%29%20is%20a%20cytokine%20with%20potent,to%20the%20host%20and%20maintaining%20normal%20tissue%20homeostasis.\">Role of Interleukin 10 Transcriptional Regulation in Inflammation and Autoimmune Disease (nih.gov)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41419-018-0765-9\">Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function | Cell Death &amp; Disease (nature.com)<\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-022-04786-y\">Clonal dynamics of haematopoiesis across the human lifespan | Nature<\/a><\/p>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>There is near universal agreement amongst health researchers that low level but continuous (chronic) inflammation in cells and tissues is a key factor in ageing itself and almost all age-related illnesses (Ref.) So much so that longevity researchers use the term &#8216;inflamm-ageing&#8217;. That inflammation can be caused by excess blood sugar, malfunctioning of the immune &#8230; <a title=\"Defeat inflammation and boost the immune system for longer healthier life\" class=\"read-more\" href=\"https:\/\/staging.nutrishield.com\/?p=14476\" aria-label=\"More on Defeat inflammation and boost the immune system for longer healthier life\">Read more<\/a><\/p>\n","protected":false},"author":5,"featured_media":13847,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_wp_rev_ctl_limit":""},"categories":[65,35],"tags":[113,199,82,77,107],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Defeat inflammation | NutriShield Comprehensive Health Supplements<\/title>\r\n<meta name=\"description\" content=\"Chronic inflammation leads to disease, so reducing inflammation and boosting the immune system helps promote longer healthier life.\" 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