{"id":4523,"date":"2016-01-14T14:07:42","date_gmt":"2016-01-14T14:07:42","guid":{"rendered":"http:\/\/www.nutrishield.com\/?p=4523"},"modified":"2016-11-22T16:14:26","modified_gmt":"2016-11-22T16:14:26","slug":"vitamin-d-depletion","status":"publish","type":"post","link":"https:\/\/staging.nutrishield.com\/?p=4523","title":{"rendered":"Vitamin D Depletion"},"content":{"rendered":"<p>Vitamin D isn\u2019t really a vitamin.<\/p>\n<p>Whatever the original source \u2013 sunlight, food or supplements\u00a0\u2013 vitamin D is turned by your liver into a hormone called calcitriol \u2013 or \u2018activated vitamin D\u2019.<\/p>\n<p>Without supplementation you get most of your vitamin D from sunlight, because surprisingly small amounts are found in a relatively few foods \u2013 oily fish, eggs and fortified spreads. Indeed the NHS website confirms:<\/p>\n<blockquote><p>\u2018It is difficult to get enough vitamin D from food alone.\u2019<\/p><\/blockquote>\n<p>Consequently, many people in the northern hemisphere are unknowingly vitamin D deficient against the standard of the Recommended Daily Amounts (RDAs) in the winter.<\/p>\n<p><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2015\/05\/sun-F-247x185.jpg\"><img  title=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-3849 size-full\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2015\/05\/sun-F-247x185.jpg\"  alt=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\"  width=\"247\" height=\"185\" \/><\/a><\/p>\n<p>People who cover their skin all the time are definitely more likely to be vitamin D deficient, as are dark-skinned people, people who work indoors all the time and older people whose skin is thinner and can process less vitamin D from sunlight. NICE \u2013 the UK&#8217;s National Institute for Health and Care Excellence \u2013 supports supplementation for these groups.<\/p>\n<p>And here is the beginning of a hot medical topic; because many health researchers now believe that the RDAs for vitamin D are too low, perhaps significantly too low.<\/p>\n<h3>Vital importance of Vitamin D in many health areas<\/h3>\n<ul>\n<li>\n<h4>Bones and Teeth<\/h4>\n<\/li>\n<\/ul>\n<p>You\u2019ll already know that Vitamin D is important for strong bones and teeth. That\u2019s because you need calcium and phosphorus to develop the structure and strength of your bones, but without without enough vitamin D your body can\u2019t absorb the minerals.<\/p>\n<ul>\n<li>\n<h4>Cancer<\/h4>\n<\/li>\n<\/ul>\n<p>But it\u2019s vitamin D\u2019s ability to influence genetic expression that produces many of its wide-ranging health benefits. Gene expression means that genes can be \u2018turned on\u2019 or up-regulated in their effect or \u2018turned off\u2019 or down-regulated.<\/p>\n<p>For example pollution, UV light, viruses and certain chemicals can switch on oncogenes (cancer causing genes). When the function of a body cell is damaged it will normally self-destruct \u2013 a process called apoptosis. But an oncogene prevents this apoptosis, allowing the cancer cell to survive and proliferate.<\/p>\n<p>A group of nutrients have been identified that lead to beneficial gene expression. They include Vitamin D \u2013 together with <strong>folic acid<\/strong>, <strong>betaine<\/strong>, <strong>vitamins B6 and B12<\/strong>,<strong> lycopene<\/strong>, <strong>curcumin<\/strong> and the <strong>polyphenols<\/strong> found in blue and red fruits. These nutrients are amongst others that appear to be able to switch on genes that normalize healthy function and some can also switch on protective genes \u2013 for example tumour suppressor genes.<\/p>\n<table border=\"0\" width=\"376\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td bgcolor=\"#ffffff\"><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2013\/04\/strew.jpg\"><img  title=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-3557 size-square\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2013\/04\/strew-180x180.jpg\"  alt=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\"  width=\"125\" height=\"125\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/strew-180x180.jpg 180w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/strew-80x80.jpg 80w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/strew-36x36.jpg 36w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/strew-120x120.jpg 120w\" sizes=\"(max-width: 125px) 100vw, 125px\" \/><\/a><\/td>\n<td bgcolor=\"#ffffff\"><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric.jpg\"><img  title=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-3579 size-square\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric-180x180.jpg\"  alt=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\"  width=\"125\" height=\"125\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric-180x180.jpg 180w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric-80x80.jpg 80w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric-36x36.jpg 36w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/turmeric-120x120.jpg 120w\" sizes=\"(max-width: 125px) 100vw, 125px\" \/><\/a><\/td>\n<td bgcolor=\"#ffffff\"><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2013\/04\/tom_glass.jpg\"><img  title=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-3577 size-square\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2013\/04\/tom_glass-180x180.jpg\"  alt=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\"  width=\"125\" height=\"125\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/tom_glass-180x180.jpg 180w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/tom_glass-80x80.jpg 80w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/tom_glass-36x36.jpg 36w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2013\/04\/tom_glass-120x120.jpg 120w\" sizes=\"(max-width: 125px) 100vw, 125px\" \/><\/a><\/td>\n<\/tr>\n<tr valign=\"top\">\n<td class=\"bottom_content\" bgcolor=\"#fbfbef\"><span style=\"color: black;\">Polyphenols from blue and red fruits<br \/>\n<\/span><\/td>\n<td class=\"bottom_content\" bgcolor=\"#fbfbef\"><span style=\"color: black;\">Curcumin from Turmeric<br \/>\n<\/span><\/td>\n<td class=\"bottom_content\" bgcolor=\"#fbfbef\"><span style=\"color: black;\"><span style=\"color: black;\">Lycopene from Tomato Juice<br \/>\n<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>The Nurses\u2019 Health Study at Harvard University revealed that women who had the highest intake of vitamin D reduced their risk of developing breast cancer by almost 50%. Positive gene expression is likely to be the underlying mechanism behind the result.<\/p>\n<p>There\u2019s another function of vitamin D that supports its benefits as an anti-cancer molecule: its role in \u2018cell signalling\u2019 \u2013 the process by which cells within your body communicate properly.<\/p>\n<p>Cells need to sense each other\u2019s boundaries. When they cannot, the result can be uncontrolled growth \u2013 cancer. Researchers have found that vitamin D (and the carotenoids like lycopene and lutein) are important in the process of normal cell signalling.<\/p>\n<p>But there are even more positive health functions of vitamin D. Optimizing your vitamin D levels can help protect against:<\/p>\n<ul>\n<li>\n<h4>Heart disease<\/h4>\n<\/li>\n<\/ul>\n<p>Dr Michael Holick is Professor of Medicine at Boston University Medical Center and a Fellow of the American College of Nutrition. He is a key vitamin D researcher and author of <em>The Vitamin D Solution<\/em>. One of his studies showed that vitamin D deficiency increased the risk of heart attack by 50 percent. Holick believes vitamin D is also important in reducing hypertension and stroke.<\/p>\n<ul>\n<li>\n<h4>DNA damage<\/h4>\n<\/li>\n<\/ul>\n<p>In one of Dr Holick&#8217;s studies, healthy volunteers taking 2,000 IUs of vitamin D per day for a few months were found to have <span style=\"text-decoration: underline;\">up<\/span>regulated 291 different genes that control many different metabolic processes. These include improving DNA repair, reducing free radical damage and boosting the immune system.<\/p>\n<ul>\n<li>\n<h4>Auto-immune diseases like MS<\/h4>\n<\/li>\n<\/ul>\n<p>Vitamin D is a powerful immune modulator, helping reduce the risk of, or ameliorate the effect of, auto-immune diseases, like MS and inflammatory bowel disease.<\/p>\n<ul>\n<li>\n<h4>Infections, including flu<\/h4>\n<\/li>\n<\/ul>\n<p>Immune cells use vitamin D. A Japanese study showed that school children taking 1,200 units of vitamin D per day during the winter time reduced their risk of contracting influenza by approximately 40 percent.<\/p>\n<ul>\n<li>\n<h4>Osteoporosis<\/h4>\n<\/li>\n<\/ul>\n<p>Women who are vitamin D deficient can lose as much as 3% to 4% of their skeletal mass per year! Vitamin D supplementation, combined with a vitamin K2 supplement and Omega 3 \u2013 and exercise\u00a0\u2013 would help counteract this.<\/p>\n<p>In summary, a lack of adequate vitamin D has been linked to cancer, heart disease, asthma, type-II diabetes, osteoporosis, high blood pressure, depression, Alzheimer\u2019s and some auto-immune diseases like multiple sclerosis, Crohn\u2019s and Type-1 diabetes \u2013 though the link to multiple sclerosis is not yet strong.<\/p>\n<h3>Are you depleted or deficient in vitamin D?<\/h3>\n<p>Researchers such as Dr Holick estimate that 50 percent of the general population of the UK or US is at risk of vitamin D deficiency and more importantly insufficiency. One deficiency symptom is tiredness.<\/p>\n<p>There is a test for blood levels of vitamin D which measures nanograms of vitamin D per millilitre of blood. The US Endocrine Society Clinical Practice Guidelines indicate a supplement level of between 40 to 60 nanograms per millilitre for the prevention and treatment of vitamin D deficiency. For people with an existing chronic disease it may well be higher.<\/p>\n<p>If you have not had the assay, however, nanograms per millilitre doesn\u2019t mean very much. Translated into what level of supplementation you should consider, the following should help:<\/p>\n<ul>\n<li>Dr Holick\u2019s recommendation for adult men and women is 2,000 IUs a day (50 mcg)<\/li>\n<li>Dr Paul Clayton\u2019s is at least 1,000 IUs a day (25 mcg) from all sources including food<\/li>\n<li>The UK\/EU RDA for food\/supplement labelling purposes is only 200 IUs \u2013 5 mcg . Indications are that this may well be increased. NICE issued guidance in 2014 that the intake for at-risk groups (see above) should be at least 10 mcg (400 IU).<\/li>\n<li>Norway has increased its RDA to 20mcg and even sunny Italy to 25mcg.<\/li>\n<li>The UK Upper Safe Limit for supplements is 800 IUs a day (20mcg), although apparently work is ongoing with a view to it being reviewed upwards. The Vitamin D Council cites potential toxicity at 40,000 IUs a day(!) taken for two months or longer.<\/li>\n<\/ul>\n<h4>But beware mono-therapy\u00a0\u2013\u00a0 use synergistic combination<\/h4>\n<p>Nutritional mono-therapy \u2013 ie taking a <span style=\"text-decoration: underline;\">single<\/span> vitamin or nutrient on its own \u2013 is never a good strategy. It\u2019s the synergistic combination of nutrients in food that is protective and the reason why you need combinations of nutrients in your supplement.<\/p>\n<p>The least you need to combine vitamin D with is <strong>vitamin K2<\/strong>. The role of K2 is to help move calcium into areas in your body, such as your bones and teeth. Vitamin K2 also helps remove calcium from areas where it shouldn&#8217;t be, such as in your arteries and soft tissues.<\/p>\n<p>But for optimum effect you would also combine with <strong>Omega 3 fish oil<\/strong>, <strong>magnesium<\/strong>, polyphenols like <strong>curcumin<\/strong> and carotenoids like <strong>lutein<\/strong> and <strong>lycopene<\/strong>.<\/p>\n<p>My overall conclusion is that a supplement level of 20 mcg \u2013 800IUs is probably the minimum therapeutic level, combined with at least 25 mcg of vitamin K2 and 650 mg of Omega 3 polyunsaturated fatty acids from fish oil \u2013 which is what is in NutriShield.<\/p>\n<hr \/>\n<p>If you enjoyed this article, please share it with family and friends (see buttons below).<\/p>\n<h4><a title=\"Register for free e-newsletters\" href=\"https:\/\/nutrishield.com\/newsletters\/\"><img  title=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\" size-medium wp-image-4565 alignright\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png\"  alt=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"106\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-495x177.png 495w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-450x159.png 450w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter.png 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>And register now for a free e-newsletter on the latest in nutrition and health research.<\/h4>\n<p>You can follow us on <a title=\"NutriShield on Facebook\" href=\"http:\/\/www.facebook.com\/nutrishield\">www.facebook.com\/nutrishield<\/a> or <a title=\"Colin Rose on Twitter\" href=\"http:\/\/www.twitter.com\/colinrose40\">www.twitter.com\/colinrose40<\/a> for daily headline health tweets.<\/p>\n<hr \/>\n<p style=\"text-align: left;\">Dr Paul Clayton designed NutriShield as a comprehensive health<a title=\"NutriShield homepage\" href=\"https:\/\/nutrishield.com\"><img  title=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\" size-full wp-image-3323 alignright\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2015\/04\/button-2.png\"  alt=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\"  width=\"180\" height=\"49\" \/><\/a> supplement with OPTIMUM levels of essential nutrients, including the highest level of vitamin D allowed under UK legislation (20mcg\/800IU ie. the government Upper Safe Limit). See more detail elsewhere on this site or click on the button.<\/p>\n<p style=\"text-align: left;\"><img  title=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-3953 alignleft\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr-230x300.jpg\"  alt=\"Vitamin D Depletion NutriShield Multi Vitamins and Minerals\"  width=\"80\" height=\"105\" \/>Dr Paul Clayton&#8217;s best-selling book <strong><em>Health Defence<\/em><\/strong> is available from most good bookstores. See the website <a title=\"Health Defence website\" href=\"http:\/\/www.healthdefence.com\">www.healthdefence.com<\/a> for excerpts and links to buy direct from the publisher.<\/p>\n<hr \/>\n<p><strong>REFERENCES<\/strong><\/p>\n<p>Meadows, Gary G. Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes. Cancer and Metastasis Reviews, 2012; DOI: 10.1007\/s10555-012-9369-5<\/p>\n<p>Huang J., Plass C., Gerhauser C. (2011) Cancer chemoprevention<br \/>\nby targeting the epigenome. Curr Drug Targets 12, 1925\u20131956<\/p>\n<p>Gerhauser C. (2013a) Cancer chemoprevention and nutriepigenetics: state of the art and future challenges. Top Curr Chem 329, 73\u2013132<\/p>\n<p>Kaulmann A, Bohn T. Carotenoids, inflammation, and oxidative stress&#8211;implications of cellular signaling pathways and relation to chronic disease prevention. Nutr Res. 2014 Nov;34(11):907-29. doi: 10.1016\/j.nutres.2014.07.010. Epub 2014 Jul 18.<\/p>\n<p>Holick, M.F. Vitamin D Deficiency. New Engl. J. Med. 2007. 357:266-81.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vitamin D isn\u2019t really a vitamin. Whatever the original source \u2013 sunlight, food or supplements\u00a0\u2013 vitamin D is turned by your liver into a hormone called calcitriol \u2013 or \u2018activated vitamin D\u2019. Without supplementation you get most of your vitamin D from sunlight, because surprisingly small amounts are found in a relatively few foods \u2013 &#8230; <a title=\"Vitamin D Depletion\" class=\"read-more\" href=\"https:\/\/staging.nutrishield.com\/?p=4523\" aria-label=\"More on Vitamin D Depletion\">Read more<\/a><\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_wp_rev_ctl_limit":""},"categories":[37,65,36,40,42,47],"tags":[94,86,90,82,72,93,91],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Vitamin D Depletion - NutriShield<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/staging.nutrishield.com\/?p=4523\" \/>\r\n<meta property=\"og:locale\" content=\"en_GB\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Vitamin D Depletion - NutriShield\" \/>\r\n<meta property=\"og:description\" content=\"Vitamin D isn\u2019t really a vitamin. Whatever the original source \u2013 sunlight, food or supplements\u00a0\u2013 vitamin D is turned by your liver into a hormone called calcitriol \u2013 or \u2018activated vitamin D\u2019. Without supplementation you get most of your vitamin D from sunlight, because surprisingly small amounts are found in a relatively few foods \u2013 ... 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