{"id":5519,"date":"2016-07-11T15:33:04","date_gmt":"2016-07-11T14:33:04","guid":{"rendered":"http:\/\/www.nutrishield.com\/?p=5519"},"modified":"2021-06-24T12:25:38","modified_gmt":"2021-06-24T11:25:38","slug":"anti-ageing-super-supplement","status":"publish","type":"post","link":"https:\/\/staging.nutrishield.com\/?p=5519","title":{"rendered":"Anti-ageing super-supplement"},"content":{"rendered":"<h4>University&#8217;s anti-ageing \u2018super-supplement\u2019 added years of full health and maintained mental agility <strong><br \/>\n<\/strong><\/h4>\n<ul>\n<li>Why <span style=\"text-decoration: underline;\">do<\/span> we become more susceptible to illness as we get older?<\/li>\n<li>Is a slow physical decline inevitable?<\/li>\n<li>What biological processes actually lead to ageing and \u2018age related disease?<\/li>\n<li>Can they be slowed or even reversed?<\/li>\n<li>Can supplements help \u2013 or are most supplements more hype than hope?<\/li>\n<\/ul>\n<p>Researchers at the Department of Biology at McMaster University, Hamilton, Ontario, Canada set out to answer those fundamental questions. Their recently published landmark study has dramatic implications for anyone interested in how to extend their years of good health, protecting normal brain and body function as they get older.<\/p>\n<p><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/07\/Seniors-singing-group-F.jpg\"><img  title=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-5528\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/07\/Seniors-singing-group-F.jpg\"  alt=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\"  width=\"387\" height=\"310\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/07\/Seniors-singing-group-F.jpg 387w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/07\/Seniors-singing-group-F-300x240.jpg 300w\" sizes=\"(max-width: 387px) 100vw, 387px\" \/><\/a><\/p>\n<h4>Fountain of Youth?<\/h4>\n<blockquote><p>Under the headline, &#8220;<strong><em>Fountain of Youth?&#8221;<\/em><\/strong> <em>Science Daily<\/em> on 2nd June 2016 announced that a multi-ingredient dietary supplement:<\/p>\n<p><em>\u201c&#8230; <\/em><em>has shown remarkable anti-aging properties that can prevent and even reverse massive brain cell loss, according to new research. It&#8217;s a mixture scientists believe could someday slow the progress of catastrophic neurological diseases such as Alzheimer&#8217;s, ALS and Parkinson&#8217;s.\u201d<\/em><\/p><\/blockquote>\n<p>The reference was to McMaster University\u2019s 10-year mouse study &#8211; which showed that combining some 30 nutritional ingredients in a \u2018super supplement\u2019 could increase healthy life span by <strong>11%<\/strong>.<\/p>\n<p>Translated into human terms, that\u2019s a projected <strong>extra 8 years of human life, with no mental decline and fully retained physical function<\/strong>.<\/p>\n<p>The university\u2019s study concludes: <em>\u201cthat powerful impacts can be achieved through multi-ingredient dietary supplementation that addresses the multi-factorial nature of ageing.\u201d <\/em><\/p>\n<h4><strong>The multi-nutrient formula<br \/>\n<\/strong><\/h4>\n<p>In 2005, lead researcher Jennifer Lemon and her team at McMaster University reviewed the effectiveness of hundreds of health supplements and concluded that there was little evidence that supplementing with a <span style=\"text-decoration: underline;\">single<\/span> ingredient \u2013 like vitamin C or beta carotene\u00a0\u2013 increased life expectancy. Even taking a single-capsule A-Z vitamin supplement had very limited effects on longevity.<\/p>\n<p>The problem, they concluded, is that most scientific studies examined only one, or at most two or three, supplement ingredients at a time \u2013 usually anti-oxidants or anti-inflammatories.<\/p>\n<p>What was needed was a supplement that combined <span style=\"text-decoration: underline;\">multiple<\/span> ingredients to get a synergistic health effect\u00a0\u2013 a \u2018best of the best\u2019 where 2+2 equals 5 in terms of health outcomes.<\/p>\n<p>So they decided that their \u2018Super Supplement\u2019 would include ingredients that had been scientifically documented as effective in counteracting the five underlying processes of ageing and the deterioration in health and mental facility usually associated with growing older.<\/p>\n<h4>The 5 health threats<\/h4>\n<h5><span style=\"text-decoration: underline;\"><span style=\"color: #ff0000;\"><strong>Threat 1<\/strong><\/span>: <strong>Oxidative stress<\/strong><\/span><\/h5>\n<p>This is the damage to cells and DNA that is done by oxidation by excess free radicals. Free radicals are highly reactive atoms produced in the body in the presence of oxygen or as a result of external pollutants. Oxidative damage is a trigger for cancer.<\/p>\n<p><strong><span style=\"color: #008000;\">Solution<\/span>:<\/strong> Anti-oxidants like Omega 3, curcumin, the polyphenols in green tea and grapeseed, lutein, vitamin C and E, the co-factors zinc and magnesium are among nutrients that can reduce this threat.<\/p>\n<h5><span style=\"text-decoration: underline;\"><strong><span style=\"color: #ff0000; text-decoration: underline;\">Threat 2<\/span>:<\/strong> <strong>Inflammation<\/strong><\/span><\/h5>\n<p>The latest research shows that inflammation builds up in body tissues and brain cells over time and is a key cause of heart disease, stroke, diabetes, and Alzheimer\u2019s. Inflammation also creates a negative internal environment which encourages the spread of cancer.<\/p>\n<p><strong><span style=\"color: #008000;\">Solution<\/span>:<\/strong> Anti-inflammatories like Omega 3 fish oil, curcumin, and green tea polyphenols are amongst effective nutrients. (Anti-oxidant nutrients often have parallel anti-inflammatory effects.)<\/p>\n<h5><span style=\"text-decoration: underline;\"><span style=\"color: #ff0000;\"><strong>Threat 3<\/strong><\/span>: <strong>Cell membrane malfunction<\/strong><\/span><\/h5>\n<p>The body creates millions of new cells every day and unless there is a supply of high quality nutrients in your diet \u2013 including anti-oxidant fatty acids \u2013 cells can fail to function properly.<\/p>\n<p><strong><span style=\"color: #008000;\">Solution<\/span>:<\/strong> A range of vitamins, minerals like zinc and selenium, and the nutrients lycopene, beta carotene and Omega 3 fish oil have been shown to reduce this threat.<\/p>\n<h5><span style=\"text-decoration: underline;\"><span style=\"color: #ff0000;\"><strong>Threat 4<span style=\"color: #000000; text-decoration: underline;\">: Insulin Resistance<\/span><\/strong><\/span><\/span><\/h5>\n<p>This is where the body\u2019s tissues develop a lower level of response to insulin. The result is that glucose (sugar) in the blood builds up to a dangerous level. This leads to what is termed \u2018glycation\u2019 \u2013 effectively cells become \u2018sugar coated\u2019 and fail to function properly. Diabetes can develop and that in turn increases the risk of vision loss, circulatory problems and dementia.<\/p>\n<p><strong><span style=\"color: #008000;\">Solution<\/span>:<\/strong> Reducing carbohydrate intake, losing weight if needed and increased intake of Omega 3 fish oil, CoQ10, chromium, magnesium and the amino-acid alpha-lipoic acid have all been shown to help reduce this threat.<\/p>\n<h5><span style=\"text-decoration: underline;\"><strong><span style=\"color: #ff0000; text-decoration: underline;\">Threat 5<\/span>: Deterioration in mitochondrial function<\/strong><\/span><\/h5>\n<p>Almost every one of your trillions of cells contains mitochondria \u2013 often called tiny \u2018energy power-plants\u2019. Their role is to extract energy from food. But their function deteriorates over time without extra nutritional help \u2013 which is why older people often complain of getting tired.<\/p>\n<p><strong><span style=\"color: #008000;\">Solution<\/span>:<\/strong> Research shows you can help prevent mitochondrial damage with anti-oxidants and supplementing with CoQ10 because your body\u2019s inbuilt ability to produce CoQ10 diminishes over time.<\/p>\n<h6>In summary, age-related decline and illness is \u2018multifactorial\u2019, so prevention by lifestyle and nutritional supplementation must equally be multi-factorial or multi-ingredient.<\/h6>\n<p>Specifically the McMaster\u2019s team reasoned that if you could prevent or reduce the risk of all 5 threats, the result should be a healthy brain, a healthy body and a longer life.<\/p>\n<p>But to achieve that, it was necessary to include not just vitamins and minerals but a <strong><span style=\"text-decoration: underline;\">combination<\/span><\/strong> of nutrients that essentially reproduced the key elements of an ideal diet. They described this combination as an MDS \u2013 a Multi-Ingredient Dietary Supplement. The press have called it a \u2018Super Supplement\u2019.<\/p>\n<h4><strong>Proof from the animal study<br \/>\n<\/strong><\/h4>\n<p>Since it is impossible to do the sort of pre- and post-treatment brain and body research that they needed to do on humans, the tests were on mice. Mice (or rats) are almost always used in these tests because their metabolism, biological processes and susceptibility to age-related disease are almost exactly the same as those of humans.<\/p>\n<h5>FOUR GROUPS OF MICE<\/h5>\n<ol>\n<li>Normal healthy mice fed a standard diet.<\/li>\n<li>TGM (<span style=\"text-decoration: underline;\">t<\/span>ransgenic <span style=\"text-decoration: underline;\">g<\/span>rowth-hormone <span style=\"text-decoration: underline;\">m<\/span>ice) fed a standard diet. This mouse strain normally ages faster, is insulin-resistant and prone to excess oxidative damage, lives for a shorter time and suffers marked brain deterioration due to loss of brain cells. This parallels Alzheimer\u2019s in humans.<\/li>\n<li>Normal mice fed with the MDS \u2013 Multi-Ingredient Dietary \u2018Super\u2019 Supplement.<\/li>\n<li>TGM mice fed with the MDS.<\/li>\n<\/ol>\n<h5>DRAMATIC RESULTS<\/h5>\n<p>The <span style=\"text-decoration: underline;\">supplemented normal mice<\/span> (group 3), compared with non-supplemented normal mice (group 1):<\/p>\n<ul>\n<li><strong>lived 11% longer<\/strong>\u00a0\u2013 about 8 years longer in human terms<\/li>\n<li>had absolutely <strong><span style=\"text-decoration: underline;\">no<\/span> deterioration in brain<\/strong> function<\/li>\n<li><strong>learned twice as fast<\/strong> as the control mice<\/li>\n<li>fully maintained <strong>motor co-ordination and vision health<br \/>\n<\/strong><\/li>\n<li>they were<strong> less anxious<\/strong><\/li>\n<li>their olfactory acuity (<strong>sense of smell<\/strong>) was undiminished<\/li>\n<li>they <strong>exercised<\/strong> as long as their younger counterparts<\/li>\n<\/ul>\n<p>In the report\u2019s words:<\/p>\n<blockquote><p>\u201c<em>The dietary supplement ameliorated key mechanisms of ageing &#8230; brain cell numbers increased and brain function improved &#8230; Retinal atrophy \u2013 associated with AMD or Macular Degeneration \u2013 was diminished.\u201d<\/em><\/p><\/blockquote>\n<p>The <span style=\"text-decoration: underline;\">supplemented TGM (genetically vulnerable) mice<\/span> (group 4), compared with the non-supplemented TGM mice:<\/p>\n<ul>\n<li><strong>lived 28% longer<\/strong> \u2013 over 20 years longer in human terms!<\/li>\n<li>their brain, sense of smell, vision and sensory functions were <strong>equivalent to far younger<\/strong> TGM mice.<\/li>\n<\/ul>\n<h5>STUDY CONCLUSIONS<\/h5>\n<p>The study concluded: &#8220;The MDS completely abolishes the severe brain cell loss, reverses cognitive decline and augments sensory and motor function in aged mice.<\/p>\n<p>&#8220;We know of no other treatment with such efficiency\u00a0<em>\u2013<\/em> highlighting the potential for prevention or amelioration of human neuro-pathologies that are similarly associated with oxidative stress, inflammation and cellular dysfunction.<\/p>\n<p>&#8220;This strongly suggests that ageing animals retain the capacity to support youthful phenotypes and that powerful impacts can be achieved through multi-ingredient dietary supplementation that addresses the multi-factorial nature of ageing.&#8221;<\/p>\n<p>The study shows that, although we do become susceptible to illnesses as we age, it is less to do with the passing of the years, than to the five threats the team identified. By supplementing with a <span style=\"text-decoration: underline;\">range<\/span> of nutrients that counteract (and even prevent) those same five threats, we can slow ageing and have a very significant and positive effect on longevity and health.<\/p>\n<p>Please see references below for the study and related research.<\/p>\n<h4>Dr Paul Clayton&#8217;s similar conclusions from 2000<\/h4>\n<p>In 2000 Dr Paul Clayton, then the Chair of the Forum of Food and Health at the UK\u2019s Royal Society of Medicine, came to <span style=\"text-decoration: underline;\">exactly<\/span> the same conclusion as McMaster University \u2013 that only a multiple-ingredient supplement can prevent declines that have multiple-factor origins.<\/p>\n<p>Dr Clayton wrote his best-selling book called \u2018<em>Health Defence\u2019<\/em> (first published 2000; updated 2004) analysing the complex causes of ageing and which foods and nutritional supplements counteracted them. Uni-Vite took up the challenge of creating his ideal multi-ingredient supplement and launched NutriShield in 2001.<\/p>\n<h4>McMaster MDS and NutriShield compared<\/h4>\n<p>The McMaster MDS formula contains 31 ingredients, the NutriShield formula contains 43.\u00a0 There are inevitably some ingredient differences \u2013 not the least that two of the original Canadian supplements are now prohibited in the UK. In addition, over the 11 years since the McMaster formula was originally decided upon, new research has strongly suggested that an ideal supplement should include some extra nutrients that were not in their formula.<\/p>\n<p>These include lycopene (indicated to help reduce the risk of breast and prostate cancer), lutein (for maintaining healthy vision) Vitamin K2 and betaine (which both help lower heart attack risk).<\/p>\n<p>In addition the McMaster formula included cod liver oil, whilst almost every health researcher would now acknowledge that Omega 3 is a far better anti-inflammatory and source of quality DHA and EPA fatty acids to build healthy cells.<\/p>\n<p>Also, whilst the McMaster formula includes ginger, research over the last 10 years has shown that curcumin (from the related plant turmeric) is a far more potent anti-inflammatory and anti-oxidant natural ingredient.<\/p>\n<p>It\u2019s natural that over the last 10 years, new research has indicated that a maximally effective MDS should now include several other ingredients \u2013 which NutriShield does.<\/p>\n<h4>PROFOUND IMPLICATIONS<strong><br \/>\n<\/strong><\/h4>\n<p>The McMaster study has profound implications. Their original concept is logical and supports the same conclusion as that made independently by Dr Paul Clayton \u2013 that the detrimental effects of ageing are less to do with the passing of the years and far more to do with multiple, inter-linked processes that lead to reduced physical functioning.<\/p>\n<p>And that these processes can be slowed or even prevented by combining a Mediterranean style diet with a carefully formulated multi-ingredient supplement, to achieve improved health, longevity, physical strength and mental acuity.<\/p>\n<p>NutriShield can be found here at <a href=\"https:\/\/nutrishield.com\">www.nutrishield.com<\/a> together with its own research results. It has been successfully and safely used for over 15 years.<\/p>\n<hr \/>\n<p>If you enjoyed this article, please share it with family and friends (see buttons below).<\/p>\n<h4><a title=\"Register for free e-newsletters\" href=\"https:\/\/nutrishield.com\/newsletters\/\"><img  title=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\" size-medium wp-image-4565 alignright\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png\"  alt=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"106\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-495x177.png 495w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-450x159.png 450w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter.png 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>And register now for a free e-newsletter on the latest in nutrition and health research.<\/h4>\n<p>You can follow us on <a title=\"NutriShield on Facebook\" href=\"http:\/\/www.facebook.com\/nutrishield\">www.facebook.com\/nutrishield<\/a> or <a title=\"Colin Rose on Twitter\" href=\"http:\/\/www.twitter.com\/colinrose40\">www.twitter.com\/colinrose40<\/a> for daily headline health tweets.<\/p>\n<hr \/>\n<p style=\"text-align: left;\">Dr Paul Clayton designed NutriShield as a comprehensive health<a title=\"NutriShield homepage\" href=\"https:\/\/nutrishield.com\"><img  title=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\" size-full wp-image-3323 alignright\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2015\/04\/button-2.png\"  alt=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\"  width=\"180\" height=\"49\" \/><\/a> supplement with OPTIMUM levels of essential nutrients. See more detail elsewhere on this site or click on the button.<\/p>\n<p style=\"text-align: left;\"><img  title=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-3953 alignleft\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr-230x300.jpg\"  alt=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\"  width=\"80\" height=\"105\" \/>Dr Paul Clayton&#8217;s best-selling book <strong><em>Health Defence<\/em><\/strong> is available from most good bookstores. See the website <a title=\"Health Defence website\" href=\"http:\/\/www.healthdefence.com\">www.healthdefence.com<\/a> for excerpts and links to buy direct from the publisher.<\/p>\n<p style=\"text-align: left;\">See online here for delicious recipes from the <em><strong>Health Defence Cookbook<\/strong><\/em>\u00a0 incorporating healthy foods featuring in a Mediterranean Diet.\u00a0<a title=\"Health Defence Cookbook\" href=\"https:\/\/nutrishield.com\/health-defence-cookbook-online\/\" target=\"_blank\" rel=\"noopener\"><img  title=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-4981\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip.png\"  alt=\"Anti-ageing super-supplement NutriShield Multi Vitamins and Minerals\"  width=\"450\" height=\"74\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip.png 1046w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip-300x49.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip-1030x168.png 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip-705x115.png 705w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip-450x74.png 450w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/a><\/p>\n<hr \/>\n<p><strong>PRIMARY REFERENCES<br \/>\n<\/strong><\/p>\n<p>J.A.Lemon, V. Aksenov, R. Samigullina, S. Aksenov, W.H. Rodgers, C.D. Rollo, D.R. Boreham. <em>A multi-ingredient dietary supplement abolishes large-scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice.<\/em> Environmental and Molecular Mutagenesis, 2016;<\/p>\n<p><a href=\"http:\/\/biomedgerontology.oxfordjournals.org\/search?author1=Jennifer+A.+Lemon&amp;sortspec=date&amp;submit=Submit\"><strong>Jennifer A. Lemon<\/strong><\/a><strong>, <\/strong><a href=\"http:\/\/biomedgerontology.oxfordjournals.org\/search?author1=Douglas+R.+Boreham&amp;sortspec=date&amp;submit=Submit\"><strong>Douglas R. Boreham<\/strong><\/a><a href=\"http:\/\/biomedgerontology.oxfordjournals.org\/content\/60\/3\/275.full#aff-2\">,\u00a0<\/a><strong>and\u00a0<\/strong><a href=\"http:\/\/biomedgerontology.oxfordjournals.org\/search?author1=C.+David+Rollo&amp;sortspec=date&amp;submit=Submit\"><strong>C. David Rollo.<\/strong><\/a> <em>A Complex Dietary Supplement Extends Longevity of Mice<\/em>, The Journals of Gerontology 2005, Vol. 60A, No. 3, 275\u2013279<\/p>\n<p>Lemon JA, Boreham DR, Rollo CD. <em>A dietary supplement abolishes age-related cognitive decline in transgenic mice expressing elevated free radical processes.<\/em> Exp Biol Med. 2003;228:800\u2013810.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>ADDITIONAL REFERENCES<br \/>\n<\/strong><\/p>\n<p>Akiyama H, Barger S, Bradt B, et al. <em>Inflammation and Alzheimer\u2019s disease. <\/em>Neurobiol Aging. 2000;21:383\u2013421.<\/p>\n<p>Ariznavarreta C, Castillo C, Segovia G, Mora F, Azcoitia I, Tresguerres JA. <em>Growth hormone and aging.<\/em> Homo. 2003;54:132\u2013141.<\/p>\n<p>Atamna H, Robinson C, Ingersoll R, Elliott H, Ames BN. <em>N-t-butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro.<\/em> FASEB J. 2001;15:2196\u20132204.<\/p>\n<p>Bartke A, Cecim M, Tang K, Steger AW, Chandrashekar V, Turyn D. <em>Neuroendocrine and reproductive consequences of overexpression of growth hormone in transgenic mice.<\/em> PSEBM 1994;206:345\u2013357.<\/p>\n<p>Beckman KB, Ames BN. <em>The free radical theory of aging matures.<\/em> Physiol Rev. 1998;78:547\u2013581.<\/p>\n<p>Bohm F, Edge R, McGarvey DJ, Truscott TG. <em>b-carotene with vitamins E and C offers synergistic cell protection against NOx.<\/em> FEBS Lett. 1998;436:387\u2013389.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Chung%20HY%5Bauth%5D\">HY Chung<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Cesari%20M%5Bauth%5D\">M Cesari<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Anton%20S%5Bauth%5D\">S Anton<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Marzetti%20E%5Bauth%5D\">E Marzetti<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Giovannini%20S%5Bauth%5D\">S Giovannini<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Seo%20AY%5Bauth%5D\">AY Seo<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Carter%20C%5Bauth%5D\">C Carter<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Yu%20BP%5Bauth%5D\">BP Yu<\/a>, and\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Leeuwenburgh%20C%5Bauth%5D\">C Leeuwenburgh. <\/a><em>Molecular Inflammation: Underpinnings of Aging and Age-related Diseases<\/em><\/p>\n<p>Dominici FP, Cifone D, Bartke A, Turyn D. <em>Loss of sensitivity to insulin at early events of the insulin signalling pathway in the liver of growth hormone-transgenic mice.<\/em> J Endocrinol. 1999;161:383\u2013392.<\/p>\n<p>Doty R L, Shaman P, Applebaum S L.\u00a0<em>et al<\/em>\u00a0<em>Smell identification ability: changes with age.<\/em>\u00a0Science 1984;226:1441\u20131443.<\/p>\n<p>Facchini FS, Hua N, Abbasi F, Reaven GM. <em>Insulin resistance as a predictor of age-related diseases.<\/em> J Clin Endocrinol Metab. 2001;86:3574\u20133578.<\/p>\n<p>Foley DJ, White LR. <em>Dietary intake of antioxidants and risk of Alzheimer disease.<\/em> JAMA. 2002;287:3261\u20133263.<\/p>\n<p>Hagen TM, Ingersoll RT, Lykkesfeld J, et al. <em>R-a-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate.<\/em> FASEB J. 1999;13:411\u2013418.<\/p>\n<p>Hagen TM, Liu J, Lykkesfeldt J, et al. <em>Feeding acetyle-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.<\/em> Proc Natl Acad Sci USA. 2002;99:1870\u20131875.<\/p>\n<p>Hauck SJ, Bartke A. <em>Free radical defenses in the liver and kidney of human growth hormone transgenic mice: possible mechanisms of early mortality.<\/em> J Gerontol Biol Sci. 2001;56A:B153\u2013B162.<\/p>\n<p>Jackson AU, Galecki AT, Burke DT, Miller RA. <em>Mouse loci associated with life span exhibit sex-specific and epistatic effects.<\/em> J Gerontol Med Sci. 2002;57A:B9\u2013B15.<\/p>\n<p>Liu J, Head E, Gharib AM, et al. <em>Memory loss in old rats is associated with brain mitochondrial decay and RNA\/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and\/or R-a-lipoic acid.<\/em> Proc Natl Acad Sci USA. 2002a;99:2356\u20132361.<\/p>\n<p>Liu J, Atamna H, Kuratsune H, Ames BN. <em>Delayed brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites.<\/em> Ann N Y Acad Sci. 2002b;959:133\u2013166.<\/p>\n<p>Matsuo M, Gomi F, Dooley MM. <em>Age-related alterations in antioxidant capacity and lipid peroxidation in brain, liver, and lung homogenates of normal and vitamin E-deficient rats.<\/em> Mech Ageing Dev. 1992;64:273\u2013292.<\/p>\n<p>Meliska CJ, Burke PA, Bartke A, Jensen RA.<em> Inhibitory avoidance and appetitive learning in aged normal mice: comparison with transgenic mice having elevated plasma growth hormone levels.<\/em> Neurobiol Learn Mem. 1997;68:1\u201312.<\/p>\n<p>Melov S. <em>Therapeutics against mitochondrial oxidative stress in animal models of aging.<\/em> Ann N Y Acad Sci. 2002;959:330\u2013340.<\/p>\n<p>Palmiter RD, Brinster RL, Hammer RE. <em>Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes.<\/em> Nature. 1982;300:611\u2013615.<\/p>\n<p>Park CR. <em>Cognitive effects of insulin in the central nervous system.<\/em> Neurosci Biobehav Rev. 2001;25:311\u2013323.<\/p>\n<p>Parr T. <em>Insulin exposure and aging theory. <\/em>Gerontology 1997;43:182\u2013200.<\/p>\n<p>Rollo CD, Carlson J, Sawada M. <em>Accelerated aging of giant transgenic mice is associated with elevated free radical processes.<\/em> Can J Zool.1996;74:606\u2013620.<\/p>\n<p>Rollo CD, Lai M, Whitehead K, Perreault ML, Lemon J, Chaudhry AM. <em>Thermoregulation of transgenic growth hormone mice.<\/em> Can J Zoo. 2004;82:934\u2013949.<\/p>\n<p>Sawada M, Carlson JC. <em>Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat.<\/em> Mech Ageing Dev. 1987;41:125\u2013137.<\/p>\n<p>Sonntag WE, Lynch CD, Cooney PT, Hutchins PM. <em>Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor-I. <\/em>Endocrinology. 1997;138:3515\u20133520.<\/p>\n<p>Steger RW, Bartke A, Cecim M. <em>Premature ageing in transgenic mice expressing different growth hormone genes.<\/em> J Reprod Fertil Suppl.1993;46:61\u201375.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University&#8217;s anti-ageing \u2018super-supplement\u2019 added years of full health and maintained mental agility Why do we become more susceptible to illness as we get older? Is a slow physical decline inevitable? What biological processes actually lead to ageing and \u2018age related disease? Can they be slowed or even reversed? Can supplements help \u2013 or are most &#8230; <a title=\"Anti-ageing super-supplement\" class=\"read-more\" href=\"https:\/\/staging.nutrishield.com\/?p=5519\" aria-label=\"More on Anti-ageing super-supplement\">Read more<\/a><\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_wp_rev_ctl_limit":""},"categories":[65,34,35],"tags":[72],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Anti Ageing Super Supplement | Nutrishield.com<\/title>\r\n<meta name=\"description\" content=\"Nutrishield is specifically formulated for healthy ageing. Includes proven anti-aging nutrients. Anti aging supplements for men and women. 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