{"id":8445,"date":"2018-03-06T14:02:15","date_gmt":"2018-03-06T14:02:15","guid":{"rendered":"https:\/\/nutrishield.com\/?p=8445"},"modified":"2018-03-06T14:19:50","modified_gmt":"2018-03-06T14:19:50","slug":"grapeseed-fights-cancer","status":"publish","type":"post","link":"https:\/\/staging.nutrishield.com\/?p=8445","title":{"rendered":"Grapeseed fights cancer"},"content":{"rendered":"<h2>The extraordinary secret of the seeds in grapes<\/h2>\n<p><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-black-bunch-C.jpg\"><img  title=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-8447 alignleft\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-black-bunch-C.jpg\"  alt=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\"  width=\"305\" height=\"361\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-black-bunch-C.jpg 305w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-black-bunch-C-253x300.jpg 253w\" sizes=\"(max-width: 305px) 100vw, 305px\" \/><\/a>The lifetime risk of getting cancer is about 53% for men and 48% for women. So good news on ways to cut that risk is important to every one of us.<\/p>\n<p><strong>Grape seeds or grapeseed extract <\/strong>may not be your first thought as part of a cancer preventative strategy, but many studies (fully referenced below) show that the seeds of grapes have important anti-cancer properties <strong>including against breast, prostate, melanoma, pancreatic and colon cancer<\/strong>.<\/p>\n<p>The reason grapeseed extract is exciting scientists in the field is that it contains compounds have been found to inhibit the mechanisms behind cancer in multiple ways. These compounds include <strong>procyanidins<\/strong>, <strong>gallic acid<\/strong> and <strong>catechins<\/strong>.<\/p>\n<h3>Grapeseeds contain multiple cancer-fighting compounds<\/h3>\n<p>A multiple approach to help prevent or treat cancer is highly desirable, because most chemotherapy drugs tackle only one or two of the mechanisms to try to stop cancer spreading (metastasising).<\/p>\n<p>Moreover, different people react in different ways to chemotherapy \u2013 as they do to nutrients in food. So the more interventions that can be used to inhibit the processes by which cancer originates, the more likely one of them is to be effective.<\/p>\n<p>The University of Colorado has been studying the ability of grapeseed extract to kill cancer cells for over 17 years. This research, together with other work at the University of Maryland Medical Center, shows that the procyanidins in grapeseed extract have been found to have three key anti-cancer mechanisms:<\/p>\n<ol>\n<li>They <strong>suppress cell-signalling<\/strong>. Signalling is key to the ability of cancer cell to grow and spread, so suppressing it helps stop that growth.<\/li>\n<li>They <strong>damp down inflammation<\/strong> which otherwise encourages the spread of cancer cells.<\/li>\n<li>They stimulate cell death \u2013 what is called <strong>apoptosis<\/strong>. Encouraging cancer cells to die is essential, because cancer involves mutated cells that proliferate and refuse to die when they should.<\/li>\n<\/ol>\n<h4><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2017\/03\/grape-seeds.jpg\"><img  title=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-6916 alignleft\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2017\/03\/grape-seeds.jpg\"  alt=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"288\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2017\/03\/grape-seeds.jpg 624w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2017\/03\/grape-seeds-300x288.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2017\/03\/grape-seeds-36x36.jpg 36w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2017\/03\/grape-seeds-450x433.jpg 450w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/h4>\n<h4>Grapeseed helps inhibit colon cancer<\/h4>\n<p>Colon and bowel cancers are the third most deadly form of cancer. Most develop from polyps in the intestine.<\/p>\n<p>Research published in the specialist cancer journal <em>Neoplasi<\/em>a has found that Grape Seed Extract (GSE) can cut the number of large polyps by as much as 70%.<\/p>\n<p>It has also been shown to reduce both the formation and the spread of cancer cells by over 80% <u>and<\/u> to help suppress tumour cells.<\/p>\n<p>Even more importantly, grapeseed extract has been shown to suppress colon cancer stem cells \u2013 which is central to eliminating a cancer.<\/p>\n<h4>Grapeseed helps inhibit prostate cancer<\/h4>\n<p>Grapeseed also includes gallic acid and this compound appears very effective in decreasing the proliferation and size of prostate tumours. Studies show that the effect is dose-dependent \u2013 starting at 50mg a day as a daily preventative dose to as high as 200mg a day as treatment.<\/p>\n<p>Other compounds in grapeseed help prevent angiogenesis \u2013 the growth of blood vessels that tumours need to maintain themselves and grow. If this blood supply is cut off, the tumours can shrink. Other research shows that a compound in soy isoflavones called genistein can do the same.<\/p>\n<p>Of course, these desirable effects are not limited to prostate cancer \u2013 so grapeseed extract is indicated as part of an overall anti-cancer strategy.<\/p>\n<h4><strong>Grapeseed <\/strong>helps inhibit <strong>breast cancer<\/strong><\/h4>\n<p>There is evidence, from a study published in <em>Breast Cancer Research Treatment<\/em>, that grapeseed can enhance the effect of one of the common breast cancer chemotherapy drugs called doxorubicin (brand name <em>Adriamycin<\/em>).<\/p>\n<p>Additionally, grapeseed\u2019s strong anti-oxidant effect has been shown to protect and maintain heart muscle. This is important, as damage to the heart can be a side-effect of breast cancer therapy.<\/p>\n<h4>Grapeseed helps inhibit ALL cancers<\/h4>\n<p>Grapeseed extract has another <strong>very<\/strong> important anti-cancer mechanism \u2013 not just for breast, but all cancers. This includes <strong>pancreatic cancer<\/strong>, which has a low survival rate and is notoriously difficult to treat.<\/p>\n<p>Grapeseed extract has been shown to reduce strongly the damaging effect of protein enzymes called MMPs (<strong>Matrix Metallo-Proteinases<\/strong>).<\/p>\n<p>MMPs are important proteins for normal wound healing. BUT in excessive numbers, they are highly damaging and can literally chew through the matrix of cells that form the outer \u2018mesh\u2019 tissue walls of internal organs. The resulting breach allows cancer cells to spread or metastasise and invade other organs.<\/p>\n<p>Grapeseed extract appears from research to be able to stop or slow the damage from MMPs and therefore help inhibit or even prevent cancer cells from spreading.<\/p>\n<p>Other compounds that appear able to do this are curcumin and the flavonoids in dark-coloured berries such as bilberry and blackcurrants \u2013 and the catechins in green tea.<\/p>\n<p>So combining all these compounds is a logical, natural, defensive strategy, as we do in the supplement <strong><u><a href=\"https:\/\/nutrishield.com\/\">NutriShield<\/a>.<\/u><\/strong><\/p>\n<h4>High doses for treatment alongside cancer drugs<\/h4>\n<p>If cancer has actually presented, however, the research indicates that high doses of grapeseed extract are needed \u2013 in conjunction with conventional cancer drugs. Some clinics are using doses as high as 1,200mg of grapeseed extract a day plus 1,000mg of curcumin taken with an oil source like Omega 3 for better bioavailability.<\/p>\n<h3>Brain health benefits of grapeseed<\/h3>\n<p><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-red-green-F.jpg\"><img  title=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-8451 alignleft\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-red-green-F.jpg\"  alt=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\"  width=\"301\" height=\"201\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-red-green-F.jpg 589w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-red-green-F-300x200.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-red-green-F-450x300.jpg 450w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-red-green-F-272x182.jpg 272w\" sizes=\"(max-width: 301px) 100vw, 301px\" \/><\/a><\/p>\n<p>Grapeseed extract is both a powerful anti-oxidant <u>and<\/u> an anti-inflammatory. There is a lot of fatty tissue in the brain and therefore it is vulnerable to oxidation or free radical damage \u2013 in rather the same way as fats will oxidise (go rancid) in the presence of air\/oxygen.<\/p>\n<p>In animal experiments, grapeseed extract was found to inhibit free radical damage to the brain and help prevent loss of cognitive ability \u2013 even in the presence of a high fat diet.<\/p>\n<p>Over the last few years, brain researchers have identified a key element in degenerative brain diseases as being the interaction in brain cells between inflammation and what is called <strong>excitotoxicity<\/strong>.<\/p>\n<p>Excitotoxity is a highly complex process, but is essentially the over-activity of certain \u2018excitatory amino acids\u2019 including glutamate, leading to neuron death and potential dementia.<\/p>\n<p>What is important is that studies show that grapeseed extract helps inhibit both inflammation <em><u>and<\/u><\/em> excitotoxicity. This may be why a study showed that patients who had been taking grapeseed extract prior to a stroke suffered less memory impairment.<\/p>\n<p><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-light-red-C.jpg\"><img  title=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-8454\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-light-red-C.jpg\"  alt=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"201\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-light-red-C.jpg 507w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-light-red-C-300x201.jpg 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-light-red-C-450x302.jpg 450w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2018\/03\/grapes-light-red-C-272x182.jpg 272w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a>In one other important study, researchers concluded that grapeseed extract \u2013 along with other flavonoids like <strong>curcuminoids<\/strong>, green tea <strong>catechins<\/strong>, <strong>apigenin<\/strong> (found in parsley and onions) and <strong>luteolin<\/strong> (found in celery, thyme and chamomile tea) \u2013 can reduce the level and effect of age-related changes in the brain. \u00a0These flavonoids appear to act against the brain-toxic sticky protein called beta-amyloid and also tau protein tangles \u2013 both characteristics of dementia and especially Alzheimer\u2019s.<\/p>\n<p>It s for these reasons that there are now human trials ongoing using grapeseed extract as a specific natural adjunct treatment for Alzheimer\u2019s.<\/p>\n<p>The brain benefits of grapeseed extract are especially important for diabetic patients who are at increased risk of neural damage. Indeed, the US Government\u2019s National Center for Complementary and Integrative Health (NCCIH) suggests the use of grapeseed in:<\/p>\n<blockquote><p>\u201c&#8230; complications related to diabetes, such as nerve and eye damage; vision problems, such as macular degeneration (which can cause blindness); swelling after an injury or surgery; cancer prevention; and wound\u00a0healing.\u201d<\/p><\/blockquote>\n<p>Finally, the multiple health benefits of grapeseed extract extend to help lowering blood pressure in overweight people and to improved heart function.<\/p>\n<h4>Start to take preventative action against cancer early<\/h4>\n<p>Although cancer appears mainly a disease of older people \u2013 most cases are first reported in over 65s \u2013 it is a slowly developing disease. So the first stages may be occurring as much as 10-15 years before it manifests itself.<\/p>\n<p>Therefore, the time to take preventative action is in the very early 50s. As you will have seen, a grapeseed extract supplement is a logical part of that action. But it\u2019s only a part, as there are many other actions you can take.<\/p>\n<p>We have created a comprehensive report on the very best ways to <u>cut the risk of cancer<\/u> \u2013 and you can read it here: <a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/11\/MaxHealthSpan3-Reduce-cancer-risk.pdf\">Reduce cancer risk and maximise your health span<\/a>.<\/p>\n<p>It is on the basis of the research outlined in this article that we have included grapeseed extract, green tea extract, soy isoflavones and curcumin in our over 50s daily health supplement <a href=\"https:\/\/nutrishield.com\/the-products\/nutrishield-premium-for-over-50s\/\"><u>NutriShield Premium<\/u><\/a>.<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p style=\"text-align: left;\">If you enjoyed this article, please share it with family and friends. You can follow us on Facebook or Twitter for daily headline health tweets.<\/p>\n<hr \/>\n<h4 style=\"text-align: left;\"><a title=\"Register for free e-newsletters\" href=\"https:\/\/nutrishield.com\/newsletters\/\"><img  title=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\" size-medium wp-image-4565 alignright\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png\"  alt=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\"  width=\"300\" height=\"106\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-300x106.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-495x177.png 495w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter-450x159.png 450w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/02\/CTA-Register-Newsletter.png 500w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a> And register now for a free regular e-newsletter on the latest in nutrition and health research.<\/h4>\n<hr \/>\n<p style=\"text-align: left;\">Dr Paul Clayton designed NutriShield as a comprehensive health<a title=\"NutriShield homepage\" href=\"https:\/\/nutrishield.com\"><img  title=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\" size-full wp-image-3323 alignright\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2015\/04\/button-2.png\"  alt=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\"  width=\"180\" height=\"49\" \/><\/a> supplement with OPTIMUM levels of essential nutrients including grapeseed extract. See more detail elsewhere on this site or click on the button.<\/p>\n<hr \/>\n<p style=\"text-align: left;\"><a href=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr.jpg\"><img  title=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\"  alt=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-3953\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr.jpg\" width=\"80\" height=\"103\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr.jpg 1392w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr-233x300.jpg 233w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr-801x1030.jpg 801w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr-1166x1500.jpg 1166w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr-548x705.jpg 548w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2015\/06\/HDbkFrontlr-450x579.jpg 450w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a>Dr Paul Clayton&#8217;s best-selling book <strong><em>Health Defence<\/em><\/strong> is available from bookstores or from Uni-Vite Healthcare <a href=\"http:\/\/www.uni-vite.com\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/p>\n<p>A free summary report and the opportunity to read the book online is available <a href=\"https:\/\/nutrishield.com\/introduction-to-health-defence-by-dr-paul-clayton\/\" target=\"_blank\" rel=\"noopener\">here<\/a>.<\/p>\n<hr \/>\n<p style=\"text-align: center;\">See online here for delicious recipes from the <em><strong>Health Defence Cookbook<\/strong><\/em>\u00a0 incorporating healthy foods featuring in a Mediterranean Diet.\u00a0<a title=\"Health Defence Cookbook\" href=\"https:\/\/nutrishield.com\/health-defence-cookbook-online\/\" target=\"_blank\" rel=\"noopener\"><img  title=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\" decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-4981\" src=\"https:\/\/nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip.png\"  alt=\"Grapeseed fights cancer NutriShield Multi Vitamins and Minerals\"  width=\"450\" height=\"74\" srcset=\"https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip.png 1046w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip-300x49.png 300w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip-1030x168.png 1030w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip-705x115.png 705w, https:\/\/staging.nutrishield.com\/wp-content\/uploads\/2016\/05\/Combined-3-courses-strip-450x74.png 450w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/a><\/p>\n<hr \/>\n<p><strong>References<\/strong><\/p>\n<p>Dietary flavonoids: Role of (-)-epicatechin and related procyanidins in cell signalling. Fraga CG,\u00a0Oteiza PI.\u00a0 <em>Free Radic Biol Med.<\/em>\u00a02011 Aug 15;51(4):813-23. doi: 10.1016\/j.freeradbiomed.2011.06.002. Epub 2011 Jun 12.<\/p>\n<p>Grape seed proanthocyanidins inhibit the proliferation, migration and invasion of tongue squamous cell carcinoma cells through suppressing the protein kinase B\/nuclear factor-\u03baB signaling pathway. Ninggang Yang, Jing Gao, Xin Cheng, Cuilan Hou, Yaya Yang, Yanxin Qiu, Mengrou Xu, Yuan Zhang and Shuangsheng Huang. <em>Int J Mol Med.<\/em> 2017 Dec; 40(6): 1881\u20131888.<\/p>\n<p>Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Veluri R,\u00a0Singh RP,\u00a0Liu Z,\u00a0Thompson JA,\u00a0Agarwal R,\u00a0Agarwal C. <em>Carcinogenesis.\u00a0<\/em>2006 Jul;27(7):1445-53. Epub 2006 Feb 10.<\/p>\n<p>Dietary Feeding of Grape Seed Extract Prevents Intestinal Tumorigenesis in APC<sup>min\/+<\/sup>\u00a0Mice. Balaiya Velmurugan, Rana P Singh, Nidhi Kaul, Rajesh Agarwal and\u00a0Chapla Agarwal. <em>Neoplasia.<\/em> 2010 Jan; 12(1): 95\u2013102.<\/p>\n<p>Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice. Wang H,\u00a0Xue Y,\u00a0Zhang H,\u00a0Huang Y,\u00a0Yang G,\u00a0Du M,\u00a0Zhu MJ. <em>Mol Nutr Food Res.<\/em>\u00a02013 Dec;57(12):2253-7. doi: 10.1002\/mnfr.201300146. Epub 2013 Aug 21.<\/p>\n<p>Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Sharma G,\u00a0Tyagi AK,\u00a0Singh RP,\u00a0Chan DC,\u00a0Agarwal R. <em>Breast Cancer Res Treat.<\/em>\u00a02004 May;85(1):1-12.<\/p>\n<p>https:\/\/www.medicalnewstoday.com\/articles\/269775.php<\/p>\n<p>Grape seed extract inhibits the growth of prostate cancer PC-3 cells. Huang TT,\u00a0Shang XJ,\u00a0Yao GH,\u00a0Ge JP,\u00a0Teng WH,\u00a0Sun Y,\u00a0Huang YF.\u00a02008 Apr;14(4):331-3.<\/p>\n<p>Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome\u00a0<em>c<\/em>\u00a0release. Chapla Agarwal, Rana P. Singh, Rajesh Agarwal. <em>Carcinogenesis<\/em>, Volume 23, Issue 11, 1 November 2002, Pages 1869\u20131876,<\/p>\n<p>Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases; Xiao-xia Dong, Yan Wang and\u00a0Zheng-hong Qin. <em>Acta Pharmacol Sin.<\/em> 2009 Apr; 30(4)<\/p>\n<p>Multi-targeted therapy of cancer by genistein. Sanjeev Banerjee, Yiwei Li,\u00a0Zhiwei Wang, and\u00a0Fazlul h. Sarkar. <em>Cancer Lett.<\/em> 2008 Oct 8; 269(2): 226\u2013242.<\/p>\n<p>Anticancer and Cancer Chemopreventive Potential of Grape Seed Extract and Other Grape-Based Products. Manjinder Kaur, Chapla Agarwal, and\u00a0Rajesh Agarwal. <em>J Nutr.<\/em> 2009 Sep; 139(9): 1806S\u20131812S.<\/p>\n<p>Grape seed extract suppresses lipopolysaccharide-induced matrix metalloproteinase (MMP) secretion by macrophages and inhibits human MMP-1 and -9 activities. La VD,\u00a0Bergeron C,\u00a0Gafner S,\u00a0Grenier D. <em>J Periodontol.\u00a0<\/em>2009 Nov;80(11):1875-82. doi: 10.1902\/jop.2009.090251.<\/p>\n<p>Grape Seed Extract and Brain Cell Rejuvenation.\u00a0 Yoo DY, Kim W, Yoo KY, Lee CH, Choi JH, Yoon YS, Kim DW, Won MH, Hwang IK. <em>Phytother Res<\/em><\/p>\n<p>Brain Bioavailability of Grape Seed Polyphenols. Mario G. Ferruzzi, Jessica K. Lobo, Elsa M. Janle, Naomi Whittaker, Bruce Cooper, James E. Simon, Qing-Li Wu, Cara Welch, Lap Ho, Connie Weaver and Giulio M. Pasinetti. <em>Journal of Alzheimer&#8217;s Disease<\/em><\/p>\n<p>Grape Seed Extract Reduces Alzheimer&#8217;s Plaque. Jun Wang, Lap Ho, Wei Zhao, Kenjiro Ono, Clark Rosensweig, Linghong Chen, Nelson Humala, David B. Teplow, and Giulio M. Pasinetti. <em>The Journal of Neuroscience<\/em><\/p>\n<p>Role of grape seed polyphenols in Alzheimer\u2019s disease neuropathology. Giulio Maria Pasinetti and\u00a0Lap Ho. <em>Nutr Diet Suppl.<\/em> 2010 Aug 1; 2010(2): 97\u2013103.<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n","protected":false},"excerpt":{"rendered":"<p>The extraordinary secret of the seeds in grapes The lifetime risk of getting cancer is about 53% for men and 48% for women. So good news on ways to cut that risk is important to every one of us. Grape seeds or grapeseed extract may not be your first thought as part of a cancer &#8230; <a title=\"Grapeseed fights cancer\" class=\"read-more\" href=\"https:\/\/staging.nutrishield.com\/?p=8445\" aria-label=\"More on Grapeseed fights cancer\">Read more<\/a><\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_wp_rev_ctl_limit":""},"categories":[37,65,47],"tags":[86,112,72],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\r\n<title>Grapeseed fights cancer - NutriShield<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/staging.nutrishield.com\/?p=8445\" \/>\r\n<meta property=\"og:locale\" content=\"en_GB\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Grapeseed fights cancer - NutriShield\" \/>\r\n<meta property=\"og:description\" content=\"The extraordinary secret of the seeds in grapes The lifetime risk of getting cancer is about 53% for men and 48% for women. 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